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1. Silverman, R.B.; Olofson, R.A. Chem. Commun., 1968, 1313. "The Oxidation of Tungsten Carbonyl in Carbon Tetrachloride."
2. Klayman, D.L.; Kenny, D.; Silverman, R.B.; Tomaszewski, J.E.; Shine, R.J. J. Org. Chem., 1971, 36, 3681-3686. "The Action
of Hydrogen Sulfide on Aminoalkanethiosulfuric Acids (Bunte Salts) to Give Di-, Tri-, and Tetrasulfides."
3. Silverman, R.B.; Dolphin, D.; Babior, B.M. J. Am. Chem. Soc., 1972, 94, 4028-4030. "A Model for the Mechanism of Action
of Coenzyme B12 Dependent Enzymes. Evidence for σĈ π Rearrangements in Cobaloximes."
4. Silverman, R.B.; Dolphin, D. J. Am. Chem. Soc., 1973, 95, 1686-1688. "A Direct Method for Cobalt-Carbon Bond Formation
in Cobalt (III)-Containing Cobalamins and Cobaloximes. Further Support for Cobalt(III) π Complexes in Coenzyme B12 Dependent
Rearrangements."
5. Silverman, R.B. in Klayman, D.L.; Gunther, W.H.H. Organic Selenium Compounds: Their Chemistry and Biology, Chapter VII, Wiley-Interscience,
New York, 1973. "Selenium Analogs of Aldehydes and Ketones."
6. Silverman, R.B. in Klayman, D.L.; Gunther, W.H.H. Organic Selenium Compounds: Their Chemistry and Biology, Chapter XI, Wiley-Interscience,
New York, 1973. "Miscellaneous Selenium-Containing Heterocycles."
7. Silverman, R.B.; Dolphin, D. J. Am. Chem. Soc., 1974, 96, 7094-7096. "Reactions of Vinyl Ethers with Cobaloximes and
Cobalamins."
8. Silverman, R.B.; Dolphin, D.; Carty, T.J.; Krodel, E.K.; Abeles, R.H. J. Am. Chem. Soc., 1974, 96, 7096-7097. "Formylcobalamin."
9. Silverman, R.B.; Dolphin, D. J. Am. Chem. Soc., 1975, 97, 2924-2925. "On the Mechanisms of Hydrolysis of β-Acetal Cobalamins."
10. Silverman, R.B.; Dolphin, D. J. Organometal. Chem., 1975, 101, C14-C16. "Hydrolysis of β-Acetal Cobaloximes."
11. Silverman, R.B.; Dolphin, D. J. Am. Chem. Soc., 1976, 98, 4626-4633. "Model Studies for Coenzyme B12-Dependent Enzyme-Catalyzed
Rearrangements: Evidence for Co(III)-p Complexes."
12. Silverman, R.B.; Dolphin, D. J. Am. Chem. Soc., 1976, 98, 4633-4639. "Model Studies for Coenzyme B12-Dependent Enzyme-Catalyzed
Rearrangements: Kinetics and Mechanism of Decomposition of Formylmethyl-cobalamin and Its Acetals."
13. Silverman, R.B.; Dolphin, D. Can. J. Chem., 1976, 54, 1425-1427. "Alkylation of the Dimethylglyoximato Ligands in Reduced Cobaloxime."
14. Silverman, R.B.; Abeles, R.H. Biochemistry, 1976, 15, 4718-4723. "Inactivation of Pyridoxal Phosphate-Dependent Enzymes by
Mono- and Polyhaloalanines."
15. Silverman, R.B.; Abeles, R.H. Biochemistry, 1977, 16, 5515-5520. "Mechanism of Inactivation of γ-Cystathionase by
β,β,β-Trifluoroalanine."
16. Silverman, R.B.; Kapili, L.V. J. Chromatography, 1978, 161, 415-416. "Paper Chromatographic and Electrophoretic Separations
of Orotic Acid, 5-Fluoroorotic Acid, 5-Fluorouracil, and 5-Fluorouridine 5'-Monophosphate."
17. Silverman, R.B. J. Heterocycl. Chem., 1978, 15, 1519-1520. "Reaction of Diethyl Acetonedicarboxylate with Nitrosyl Chloride."
18. Silverman, R.B.; Kapili, L.V. J. Label. Compounds Radiopharm., 1979, 16, 361-364. "Synthesis of [Carboxyl-14C]5-Fluoroorotic Acid."
19. Silverman, R.B.; Hoffman, S.J. in Kalman, T.I. (Edit.) Drug Action and Design: Mechanism-Based Enzyme Inhibitors, Elsevier-North Holland, N.Y., 1979, pp 175-186, "Mechanism of Inactivation of Mitochondrial Monoamine Oxidase by Cyclopropylamines."
20. Silverman, R.B.; Hoffman, S.J. in Singer, T.P.; Von Korff, R.W.; Murphy, D.L. (Edit.) Monoamine Oxidase: Structure, Function, and Altered Functions,
Academic Press, N.Y., 1979, pp 71-79, "Mechanism of Inactivation of Monoamine Oxidase by N-Cyclopropyl-N-Arylalkyl Amines."
21. Silverman, R.B.; Radak, R.E.; Hacker, N.P. J. Org. Chem., 1979, 44, 4970-4971. "A Mild Method of Hydrolysis of 2,4-Dialkoxy-6-Substituted
Pyrimidines to 6-Substituted Uracils."
22. Dolphin, D.; Banks, A.R.; Cullen, W.R.; Cutler, A.R.; Silverman, R.B. in Zagalak, B.; Friedrich, W. (Edit.) Proceedings of the Third European
Symposium on Vitamin B12 and Intrinsic Factor, Walter deGruyter, Inc., Berlin and N.Y., 1979. "The Mechanism of Action
of Coenzyme B12."
23. Bulkowski, J.; Cutler, A.; Dolphin, D.; Silverman, R.B. Inorganic Syntheses, 1980, 20, 127-134. "Bis[2,3-butanedionedioximato
(1-)]cobalt Complexes."
24. Dolphin, D.; Halko, D.J.; Silverman, R.B. Inorganic Syntheses, 1980, 20, 134-142. "Cobalamins and Cobinamides."
25. Silverman, R.B.; Levy, M.A. J. Org. Chem., 1980, 45, 815-818. "Syntheses of (S)-5-Substituted-4-Aminopentanoic Acids:
A New Class of γ-Aminobutyric Acid Transaminase Inactivators."
26. Silverman, R.B.; Hoffman, S.J. J. Am. Chem. Soc., 1980, 102, 884-886. "Mechanism of Inactivation of Mitochondrial Monoamine
Oxidase by N-Cyclopropyl-N-Arylalkyl Amines."
27. Silverman, R.B.; Dolphin, D. J. Chromatography, 1980, 194, 273-274. "Thin-Layer Chromatography of Acid-Labile Cobalamins."
28. Silverman, R.B. J. Am. Chem. Soc., 1980, 102, 5421-5423. "A Model for a "Molecular Mechanism of Anticoagulant
Activity of 3-Substituted-4-Hydroxycoumarins.">
29. Silverman, R.B.; Levy, M.A. Biochem. Biophys. Res. Comm., 1980, 95, 250-255. "Irreversible Inactivation of Pig Brain γ-Aminobutyric
Acid-α-Ketoglutarate Transaminase by 4-Amino-5-halopentanoic Acids."
30. Silverman, R.B.; Hoffman, S.J.; Catus, W.B., III J. Am. Chem. Soc., 1980, 102, 7126-7128. "A Mechanism for Mitochondrial Monoamine
Oxidase-Catalyzed Amine Oxidation."
31. R.B. Silverman, J. Am. Chem. Soc., 1981, 103, 3910-3915. "Model Studies for a Molecular Mechanism of Action of Oral
Anticoagulants."
32. Silverman, R.B.; Hoffman, S.J. J. Label. Compounds Radiopharm., 1981, 18, 781-790. "Syntheses of N-[1-2H]-, N-[1-3H]cyclopropylbenzylamine
and [phenyl-14C]N-cyclopropylbenzylamine."
33. Silverman, R.B.; Levy, M.A. Biochemistry, 1981, 20, 1197-1203. "Mechanism of Inactivation of γ-Aminobutyric Acid-α-Ketoglutaric
Acid Aminotransferase by 4-Amino-5-halopentanoic Acids."
34. Silverman, R.B.; Levy, M.A. J. Biol. Chem., 1981, 256, 11565-11568. "Substituted 4-Aminobutanoic Acids: Substrates for γ-Aminobutyric
Acid-α-Ketoglutaric Acid Aminotransferase."
35. Silverman, R.B. J. Am. Chem. Soc., 1981, 103, 5939-5941, "Chemical Model Studies for the Mechanism of Vitamin K Epoxide
Reductase."
36. Silverman, R.B. J. Org. Chem., 1981, 46, 4789-4791, "Mechanism of Isomerization of a β-Ketosulfide."
37. Silverman, R.B.; Hoffman, S.J. Biochem. Biophys. Res. Commun. 1981, 101, 1396-1401. "N-(1-Methyl)Cyclopropylbenzylamine:
A Novel Inactivator of Mitochondrial Monoamine Oxidase."
38. Silverman, R.B.; Levy, M.A.; Muztar, A.J.; Hirsch, J.D. Biochem. Biophys. Res. Commun., 1981, 102, 520-523. "In Vivo Inactivation
of γ-Aminobutyric Acid-α-Ketoglutarate Transaminase by 4-Amino-5-fluoropentanoic Acid."
39. Silverman, R.B.; Holladay, M.W. J. Am. Chem. Soc., 1981, 103, 7357-7358. "Stereospecific Total Syntheses of the Antitumor
Agent [αS,5S]-α-Amino-3-chloro-4,5-dihydro-5-isoxazoleacetic Acid and Its C-5 Epimer."
40. Silverman, R.B.; Hoffman, S.J.; Catus, W.B., III in Flavins and Flavoproteins, (V. Massey and C.H. Williams, Jr., eds.) Elsevier-North Holland,
N.Y., 1982, pp. 213-216, "A Mechanism for Mitochondrial Monoamine Oxidase-Catalyzed Amine Oxidation."
41. Silverman, R.B.; Groziak, M.P. J. Am. Chem. Soc., 1982, 104, 6434-6439. "Model Chemistry for a Covalent Mechanism of Action
of Orotidine 5'-Phosphate Decarboxylase."
42. Silverman, R.B.; Muztar, A.J.; Levy, M.A.; Hirsch, J.D. Life Sci., 1983, 32, 2717-2723. "In Vitro and In Vivo Effects on Brain
GABA Metabolism of (S)-4-Amino-5-fluoropentanoic Acid, A Mechanism-based Inactivator of γ-Aminobutyric Acid Transaminase."
43. Silverman, R.B. J. Biol. Chem., 1983, 258, 14766-14769. "Mechanism of Inactivation of Monoamine Oxidase by trans-2-Phenylcyclopropylamine
and the Structure of the Enzyme-Inactivator Adduct."
44. Silverman, R.B.; Hoffman, S.J. Med. Res. Rev., 1984, 4, 415-447. "The Organic Chemistry of Mechanism-Based Enzyme Inhibition:
A Chemical Approach to Drug Design."
45. Silverman, R.B.; Yamasaki, R.B. Biochemistry, 1984, 23, 1322-1332. "Mechanism-based Inactivation of Mitochondrial Monoamine
Oxidase by N-(1-Methylcyclopropyl)benzylamine."
46. Silverman, R.B. Biochemistry, 1984, 23, 5206-5213. "Effect of a-Methylation on the Inactivation of Monoamine Oxidase by N-Cyclopropylbenzylamine."
47. Silverman, R.B.; Tan, J.L. J. Org. Chem., 1984, 49, 4560-4562, "Mechanism for the Reaction of trans-2-Phenylcyclopropylamine
with Nitrous Acid."
48. Silverman, R.B.; Zieske, P.A. Biochemistry, 1985, 24, 2128-2138, "Mechanism of Inactivation of Monoamine Oxidase by 1-Phenylcyclopropylamine."
49. Mukharji, I.; Silverman, R.B. Proc. Natl. Acad. Sci. (USA), 1985, 82, 2713-2717, "Purification of a Vitamin K Epoxide
Reductase Which Catalyzes the Conversion of Vitamin K 2,3-epoxide to 3-Hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone."
50. Mathew, J.; Invergo, B.J.; Silverman, R.B. Syn. Commun., 1985, 15, 377-383. "An Efficient Synthesis of 3-Amino-4-fluorobutanoic
Acid, an Inactivator of GABA Transaminase."
51. Silverman, R.B.; Zieske, P.A. J. Med. Chem., 1985, 28, 1953-1957. "1-Benzylcyclopropylamine and (1-Phenylcyclopropyl)methylamine,
an Inactivator and a Substrate of Monoamine Oxidase."
52. Vazquez, M.L.; Silverman, R.B. Biochemistry, 1985, 24, 6538-6543, "Revised Mechanism for Inactivation of Mitochondrial Monoamine
Oxidase by N-Cyclopropylbenzylamine."
53. Yamasaki, R.B.; Silverman, R.B. Biochemistry, 1985, 24, 6543-6550, "Mechanism for Reactivation of N-Cyclopropylbenzylamine-Inactivated
Monoamine Oxidase by Amines."
54. Silverman, R.B.; Hiebert, C.K.; Vazquez, M.L. J. Biol. Chem., 1985, 260, 14648-14652, "Inactivation of Monoamine Oxidase
by Allylamine Does Not Result in Flavin Attachment."
55. Silverman, R.B.; Durkee, S.C.; Invergo, B.J. J. Med. Chem., 1986, 29, 764-770. "4-Amino-2-(substituted methyl)-2-butenoic
Acids: Substrates and Potent Inhibitors of γ-Aminobutyric Acid Aminotransferase."
56. Silverman, R.B. in Protein Tailoring for Food and Medical Uses (R.E. Feeney and J.R. Whitaker, Eds.), Marcel Dekker, N.Y., 1986, Chapter
8, pp 215-241, "Mechanism-Based Enzyme Inactivators for Medical Uses."
57. Silverman, R.B.; Zieske, P.A. Biochemistry, 1986, 25, 341-346, "1-Phenylcyclobutylamine, the First in a New Class of Monoamine
Oxidase Inactivators. Further Evidence for a Radical Intermediate."
58. Silverman, R.B.; Zieske, P.A. Biochem. Biophys. Res. Commun., 1986, 135, 154-159, "Identification of the Amino Acid Bound
to the Labile Adduct Formed During Inactivation of Monoamine Oxidase by 1-Phenylcyclopropylamine."
59. Silverman, R.B.; Invergo, B.J.; Mathew, J. J. Med. Chem., 1986, 29, 1840-1846, "Inactivation of γ-Aminobutyric Acid Aminotransferase
by (S,E)-4-Amino-5-fluoropent-2-enoic Acid and Effect on the Enzyme of (E)-3-(1-Aminocyclopropyl)-2-propenoic Acid."
60. Silverman, R.B.; Invergo, B.J. Biochemistry, 1986, 25, 6817-6820, "Mechanism of Inactivation of γ-Aminobutyrate Aminotransferase
by 4-Amino-5-fluoropentanoic Acid. First Example of an Enamine Mechanism for a γ-Amino Acid with a Partition Ratio of O."
61. Silverman, R.B.; Invergo, B.J.; Levy, M.A.; Andrew, C.R. J. Biol. Chem., 1987, 262, 3192-3195, "Substrate Stereospecificity
and Active Site Topography of γ-Aminobutyric Acid Aminotransferase for β-Aryl-γ-aminobutyric Acid Analogues."
62. Silverman, R.B.; Banik, G.M. J. Am. Chem. Soc., 1987, 109, 2219-2220, "(Aminoalkyl)trimethylsilanes. A New Class of
Monoamine Oxidase Inactivators."
63. Silverman, R.B.; Vadnere, M.K. Bioorg. Chem., 1987, 15, 328-332, "Aminoalkyltrimethylgermanes: The First Organogermanium Mechanism-Based
Enzyme Inactivators. A New Class of Monoamine Oxidase Inactivators."
64. Silverman, R.B.; Mukharji, I.; Nandi, D.L. in Current Advances in Vitamin K Research (J. W. Suttie, Ed.), Elsevier/North-Holland, New York,
1988, 65-74, "Solubilization, Partial Purification, Mechanism, and Inactivation of Vitamin K Epoxide Reductase."
65. Silverman, R.B.; George, C. Biochem. Biophys. Res. Commun. 1988, 150, 942-946, "Mechanism of Inactivation of γ-Aminobutyric
Acid Aminotransferase by (S,E)-4-Amino-5-fluoropent-2-enoic Acid."
66. Silverman, R.B. J. Enz. Inhib. 1988, 2, 73-90, "The Potential Use of Mechanism-Based Enzyme Inactivators in Medicine."
67. Silverman, R.B. in Topics in Medicinal Chemistry (4th SCI-RSC Medicinal Chemistry Symposium; P. R. Leeming, Ed., Royal Society of Chemistry,
London, 1988, pp. 73-100, "Enzyme Inhibition: Approaches to Drug Design."
68. Silverman, R.B.; George, C. Biochemistry, 1988, 27, 3285-3289, "Inactivation of γ-Aminobutyric Acid Aminotransferase by
(Z)-4-Amino-2-fluoro-2-butenoic Acid."
69. Hiebert, C.K.; Silverman, R.B. J. Med. Chem., 1988, 31, 1566-1570, "1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
(MPTP) Analogues. Inactivation of Monoamine Oxidase by Conformationally-Rigid Analogues of N,N-Dimethylcinnamylamine."
70. Silverman, R.B.; Hiebert, C.K. Biochemistry, 1988, 27, 8448-8453, "Inactivation of Monoamine Oxidase A by the Monoamine Oxidase
B Inactivators 1-Phenylcyclopropylamine, 1-Benzylcyclopropylamine, and N-Cyclopropyl-β-methylbenzylamine."
71. Silverman, R.B.; Nandi, D.L. Biochem. Biophys. Res. Commun. 1988, 155, 1248-1254, "Reduced Thioredoxin: A Possible Physiological
Cofactor for Vitamin K Epoxide Reductase. Further Support for an Active Site Disulfide."
72. Yelekci, K.; Lu, X.; Silverman, R.B. J. Am. Chem. Soc. 1989, 111, 1138-1140, "Electron Spin Resonance Studies of Monoamine
Oxidase B. First Direct Evidence for a Substrate Radical Intermediate."
73. Silverman, R.B.; Oliver, J. S. J. Med. Chem., 1989, 32, 2138-2141, "2-Fluoromethyl-3-phytyl-1,4-naphthoquinone and its 2,3-Epoxide.
Inhibition of Vitamin K Epoxide Reductase."
74. Andruszkiewicz, R.; Silverman, R.B. Synthesis, 1989, 953-955, "A Convenient Synthesis of 3-Alkyl-4-aminobutanoic Acids."
75. Gates, K.S.; Silverman, R.B. J. Am. Chem. Soc., 1989, 111, 8891-8895, "Model Studies for the Mechanism of Inactivation of Monoamine
Oxidase by 5-Aminomethyl-3-aryl-2-oxazolidinones."
76. Nanavati, S.M.; Silverman, R.B. J. Med. Chem., 1989, 32, 2413-2421, "Design of Potential Anticonvulsant Agents: Mechanistic
Classification of γ-Aminobutyric Acid Aminotransferase Inactivators."
77. Hiebert, C.K.; Sayre, L.M.; Silverman, R.B. J. Biol. Chem., 1989, 264, 21516-21521, "Inactivation of Monoamine Oxidase
by 3,3-Dimethyl Analogues of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and 1-Methyl-4-phenyl-2,3-dihydropyridinium Ion (MPDP+).
Dramatic effect of β-Mercaptoethanol on Substrate Turnover and Enzyme Inactivation."
78. Silverman, R.B.; Nanavati, S.M. J. Med. Chem., 1990, 33, 931-936, "Selective Inhibition of γ-Aminobutyric Acid Aminotransferase
by (3R,4R),(3S,4S) and (3R,4S),(3S,4R)-4-Amino-5-fluoro-3-phenylpentanoic Acids."
79. Andruszkiewicz, R.; Barrett, A.G.M.; Silverman, R.B. Syn. Commun., 1990, 20, 159-166, "Chemoenzymatic Synthesis of (R)-
and (S)-4-Amino-3-methylbutanoic Acids."
80. Ryall, R.P.; Silverman, R.B. Syn. Commun., 1990, 20, 431-438, "Synthesis of 2-Substituted-3-phytyl-1,4-naphthoquinone Epoxides."
81. Banik, G.M.; Silverman, R.B. J. Am. Chem. Soc., 1990, 112, 4499-4507, "Mechanism of Inactivation of Monoamine Oxidase B by (Aminomethyl)trimethylsilane."
82. Silverman, R.B.; Nandi, D.L. J. Enz. Inhib. 1990, 3, 289-294, "Effect of N-Ethylmaleimide on Beef and Rat Liver Vitamin
K1 Epoxide Reductase."
83. Ryall, R.P.; Nandi, D.L.; Silverman, R.B. J. Med. Chem., 1990, 33, 1790-1797, "Substituted Vitamin K Epoxide Analogues. New
Competitive Inhibitors and Substrates of Vitamin K1 Epoxide Reductase."
84. Gates, K.S.; Silverman, R.B. J. Am. Chem. Soc., 1990, 112, 9364-9372, "5-(Aminomethyl)-3-aryl-2-oxazolidinones. A Novel Class of
Mechanism-Based Inactivators of Monoamine Oxidase B."
85. Andruszkiewicz, R.; Silverman, R.B. J. Biol. Chem., 1990, 265, 22288-22291, "4-Amino-3-alkylbutanoic Acids as Substrates
for γ-Aminobutyric Acid Aminotransferase."
86. Silverman, R.B. Biochem. Soc. Trans., 1991, 19, 201-206, "The Use of Mechanism-Based Inactivators to Probe the Mechanism
of Monoamine Oxidase."
87. Silverman, R.B.; Andruszkiewicz, R.; Nanavati, S.M.; Taylor, C.P.; Vartanian, M.G. J. Med. Chem., 1991, 34, 2295-2298. "3-Alkyl-4-aminobutyric
Acids: The First Class of Anticonvulsant Agents That Activates L-Glutamic Acid Decarboxylase."
88. Burke, J.R.; Silverman, R.B. J. Enz. Inhib., 1991, 5, 199-205. "4-(Oxoalkyl)-substituted
GABA Analogues as Inactivators and Substrates of GABA Aminotransferase."
89. Burke, J.R.; Silverman, R.B. J. Am. Chem. Soc., 1991, 113, 9329-9340. "Mechanism of Inactivation of γ-Aminobutyric Acid Aminotransferase
by 4-Amino-5-hexynoic Acid (γ-Ethynyl GABA)."
90. Nanavati, S.M.; Silverman, R.B. J. Am. Chem. Soc., 1991, 113, 9341-9349. "Mechanisms of Inactivation of γ-Aminobutyric
Acid Aminotransferase by the Antiepilepsy Drug γ-Vinyl GABA (Vigabatrin)."
91. Taylor, C.P.; Vartanian, M.G.; Andruszkiewicz, R.; Silverman, R.B. Epilepsy Res. 1992, 11, 103-110. "3-Alkyl GABA and
3-Alkylglutamate Analogues: Two New Classes of Anticonvulsant Agents."
92. Ding, Z.; Silverman, R.B. J. Med. Chem. 1992, 35, 885-889. "5-(Aminomethyl)-3-aryldihydrofuran-2(3H)-ones,
a New Class of Monoamine Oxidase-B Inactivators."
93. Silverman, R.B. In Advances in Electron Transfer Chemistry, Vol. 2; Mariano, P.S., Ed.; JAI Press: Greenwich, CT, 1992; pp. 177-213. "Electron Transfer Chemistry of Monoamine Oxidase."
94. Hopkins, M.H.; Silverman, R.B. J. Enz. Inhib. 1992, 6, 125-129. "β-Lactams: A New Class of Conformationally-Rigid Inhibitors
of γ-Aminobutyric Acid Aminotransferase."
95. Hopkins, M.H.; Silverman, R.B. BioMed. Chem. Lett. 1992, 2, 1371-1374. "α-Amino Acid Analogues as Mechanism-Based Inactivators
of γ-Aminobutyric Acid Aminotransferase."
96. Hopkins, M.H.; Bichler, K.A.; Su, T.; Chamberlain, C.L.; Silverman, R.B. J. Enz. Inhib. 1992, 6, 195-199. "Inactivation
of γ-Aminobutyric Acid Aminotransferase by Various Amine Buffers."
97. Ding, C.Z.; Silverman, R.B. J. Enz. Inhib. 1992, 6, 223-231. "4-(Aminomethyl)-1-Aryl-2-pyrrolidinones,
a New Class of Monoamine Oxidase B Inactivators."
98. Zelechonok, Y.; Silverman, R.B. J. Org. Chem. 1992, 57, 5785-5787. "Mechanism for the Reaction of Tributyltin Radicals with
Aldehydes."
99. Zelechonok, Y.; Silverman, R.B. J. Org. Chem. 1992, 57, 5787-5790. "Silver (I)/Peroxydisulfate-Induced Oxidative Decarboxylation
of Amino Acids. A Chemical Model for a Possible Intermediate in the Monoamine Oxidase-Catalyzed Oxidation of Amines."
100. Silverman, R.B.; Zelechonok, Y. J. Org. Chem. 1992, 57, 6373-6374. "Evidence for a Hydrogen Atom Transfer Mechanism or a Proton/Fast
Electron Transfer Mechanism for Monoamine Oxidase."
101. Silverman, R.B.; Lu, X.L.; Banik, G.M. J. Org. Chem. 1992, 57, 6617-6622. "Formylsilanes. Chemoenzymatic and Chemical Syntheses
of the 2,4-Dinitrophenylhydrazones of These Apparently Air- and Water-Stable Compounds."
102. Silverman, R.B.; Ding, C.Z.; Gates, K.S. Perspectives in Medicinal Chemistry ; Testa, B.; Kyburz, E.; Fuhrer, W.; Giger, R., Eds.; Verlag Helvetica
Chimica Acta: Basel; 1993, 73-86. "Design and Mechanism of Monoamine Oxidase Inactivators from a Chemical Perspective."
103. Silverman, R.B.; Nishimura, K.; Lu, X. J. Am. Chem. Soc. 1993, 115, 4949-4954. "Mechanism of Inactivation of Monoamine Oxidase-B
by the Anticonvulsant Agent Milacemide (2-(n-Pentylamino)acetamide)."
104. Silverman, R.B.; Ding, C.Z.; Borrillo, J.L.; Chang, J.T. J. Am. Chem. Soc. 1993, 115, 2982-2983. " Mechanism-Based Enzyme Inactivation
via a Diactivated Cyclopropane Intermediate."
105. Nishimura, K.; Lu, X.; Silverman, R.B. J. Med. Chem. 1993, 36, 446-448. "Inactivation of Monoamine Oxidase B by Analogues
of the Anticonvulsant Agent Milacemide (2-n-Pentylaminoacetamide)."
106. Silverman, R.B.; Cesarone, J.M.; Lu, X. J. Am. Chem. Soc. 1993, 115, 4955-4961. "Stereoselective Ring Opening of 1-Phenylcyclopropylamine
Catalyzed by Monoamine Oxidase-B."
107. Silverman, R. B.; Ding, C.Z. J. Am. Chem. Soc. 1993, 115, 4571-4576. "A Chemical Model for the Mechanism of Inactivation
of Monoamine Oxidase by Heterocyclic Compounds. Electronic Effects on Acetal Hydrolysis"
108. Lu, X.; Silverman, R.B. J. Enz. Inhib. 1993, 7, 43-45. "The Antiulcer Drug Ranitidine Hydrochloride and its Synthetic Intermediates
are Inactivators of Monoamine Oxidase-B."
109. Ding, C.Z.; Silverman, R.B. Syn. Commun. 1993, 23, 1467-1471. "Synthesis of N-Carbobenzoxy-N,N-acetals."
110. Ding, C.Z.; Lu, X.; Nishimura, K.; Silverman, R.B. J. Med. Chem., 1993, 36, 1711-1715. "Transformation of Monoamine Oxidase-B
Primary Amine Substrates into Time-Dependent Inhibitors. Tertiary Amine Homologues of Primary Amine Substrates."
111. Silverman, R.B.; Tran, N.; Sinha, R.K.; Neuhaus, F.C. Biochem. Biophys. Res. Commun. 1993, 195, 1077-1080. "The Oxazolidinone
Antibacterial Agent DuP 105 Does Not Act on Cell Wall Biosynthesis or on a β-Lactamase."
112. Ding, C. Z.; Silverman, R. B. BioMed. Chem. Lett. 1993, 3, 2077-2078. "Selective Inactivation of Monoamine Oxidase B
by Aminoethyl 3-Chlorobenzyl Ether."
113. Silverman, R. B.; Zhou, J. P.; Eaton, P. E. J. Am. Chem. Soc. 1993, 115, 8841-8842. "Inactivation of Monoamine Oxidase
by (Aminomethyl)cubane. First Evidence for an α-Amino Radical During Enzyme Catalysis."
114. Ding, C. Z.; Silverman, R. B. J. Med. Chem. 1993, 36, 3606-3610. "Transformation of Heterocyclic Reversible Monoamine
Oxidase-B Inactivators into Irreversible Inactivators by N-Methylation."
115. Annan, N.; Silverman, R. B. J. Med. Chem., 1993, 36, 3968-3970. "New Analogues of N-(2-Aminoethyl)-4-chlorobenzamide
(Ro 16-6491). Some of the Most Potent Monoamine Oxidase-B Inactivators."
116. Silverman, R. B.; Lu, X. J. Am. Chem. Soc. 1994, 116, 4129-4130. "Evidence Against a Nucleophilic Mechanism for Monoamine
Oxidase-Catalyzed Amine Oxidation."
117. Woo, J. C. G.; Silverman, R. B. Biochem. Biophys. Res. Commun. 1994, 202, 1574-1578. "Observation of Two Different Chromophores
in the Resting State of Monoamine Oxidase B by Fluorescence Spectroscopy."
118. Silverman, R. B.; Lu, X.; Zhou, J. J. P.; Swihart, A. J. Am. Chem. Soc. 1994, 116, 11590-11591. "Monoamine Oxidase
B-Catalyzed Oxidation of Cinnamylamine-2,3-oxide. Further Evidence against a Nucleophilic Mechanism."
119. Silverman, R. B.; Olson, G. T. Bioorg. Med. Chem., 1995, 3, 11-18. "Inactivation of γ-Aminobutyric Acid Aminotransferase
by L-3-Chloroalanine Hydroxamate."
120. Silverman, R. B. Methods Enzymol. 1995, 249, 240-283. "Mechanism-Based Enzyme Inactivators."
121. Silverman, R. B.; Hawe, W. P. J. Enz. Inhib., 1995, 9, 203-215. "SAR Studies of Fluorine-Substituted Benzylamines
and Substituted 2-Phenylethylamines as Substrates and Inactivators of Monoamine Oxidase B."
122. Silverman, R. B. Prog. Brain Res. 1995, 106, 23-31. "Radical Thoughts about the Life of MAO."
123. Woo, J. C. G.; Silverman, R. B. J. Am. Chem. Soc., 1995, 117, 1663-1664. "Monoamine Oxidase B Catalysis in Low Aqueous
Medium. Direct Evidence for an Imine Product."
124. Zhou, J. J. P.; Zhong, B.; Silverman, R. B. J. Org. Chem. 1995, 60, 2261-2262. "Improved Procedure for the Synthesis
of Substituted β-Hydroxynitriles."
125. Lightcap, E. S.; Hopkins, M. H.; Olson, G. T.; Silverman, R. B. Bioorg. Med. Chem. 1995, 3, 579-585. "Time-Dependent
Inhibition of γ-Aminobutyric Acid Aminotransferase by 3-Hydroxybenzylhydrazine."
126. Silverman, R. B.; Olson, G. T. J. Org. Chem. 1995, 60, 6232-6234. "Mechanism of Inactivation of γ-Aminobutyric Acid
Aminotransferase by 3-Hydrazinopropionic Acid."
127. Woo, J. C. G.; Wang, X.; Silverman, R. B. J. Org. Chem. 1995, 60, 6235-6236. "Monoamine Oxidase-Catalyzed Amine Oxidation in
Organic Solvents."
128. Silverman, R. B. Acc. Chem. Res. 1995, 28, 335-342. "Radical Ideas About Monoamine Oxidase."
129. Silverman, R. B.; Zhou, J. J. P.; Ding, C. Z.; Lu, X. J. Am. Chem. Soc. 1995, 117, 12895- 12896. "Monoamine Oxidase-Catalyzed
Oxidative Decarboxylation of cis- and trans-5- Aminomethyl-3-(4-methoxyphenyl)dihydrofuran-2(3H)-one. Evidence for the Intermediacy of an α-Radical."
130. Lightcap, E. S.; Silverman, R. B. J. Med. Chem. 1996, 39, 686-694. "Slow-binding Inhibition of γ-Aminobutyric Acid
Aminotransferase by Hydrazine Analogues."
131. Zhou, J. J. P.; Zhong, B.; Silverman, R. B. Anal. Biochem. 1996, 234, 9-12. "Direct Continuous Fluorometric Assay for
Monoamine Oxidase B."
132. Silverman, R. B.; Bichler, K. A.; Leon, A. J. J. Am. Chem. Soc. 1996, 118, 1241-1252. "Mechanisms of Inactivation of γ-Aminobutyric Acid Aminotransferase by 4-Amino-5-fluoro-5-hexenoic Acid."
133. Silverman, R. B.; Bichler, K. A.; Leon, A. J. J. Am. Chem. Soc. 1996, 118, 1253-1261. "Unusual Mechanistic Difference in
the Inactivation of γ-Aminobutyric Acid Aminotransferase by (E)- and (Z)-4-Amino-6-fluoro-5-hexenoic Acids."
134. Silverman, R. B.; Olson, G. T. Bioorg. Med. Chem. Lett. 1996, 6, 143-146. "3-Substituted Alanines Inactivate γ-Aminobutyric
Acid Aminotransferase by the Same Mechanism as do 4-Amino-5-halopentanoic Acid Analogues."
135. Silverman, R. B.; Roscher, C. L.C. Bioorg. Med. Chem. 1996, 4,
1521-1535. "Mechanism-Based Inactivation of γ-Aminobutyric Acid Aminotransferase by 3-Amino-4-fluorobutanoic Acid."
136. Leon, A. J.; Silverman, R. B. Bioorg. Med. Chem. Lett. 1996, 6, 1319-1322. "Inactivation of γ-Aminobutyric Acid
Aminotransferase by (Z)-4-Amino-6-fluoro-5-hexenoic Acid: Identification of an Active Site Residue."
137. DeRose, V.J.; Woo, J.C.G.; Hawe, W.P.; Hoffman, B.M.; Silverman, R.B.; Yelekci, K. Biochemistry 1996, 35, 11085-11091. "Characterization
of a Flavin Semiquinone in the Resting State of Monoamine Oxidase B by Electron Paramagnetic Resonance and Electron Nuclear Double Resonance Spectroscopy."
138. Silverman, R. B. In Contemporary Enzyme Kinetics and Mechanism, 2nd edition; Purich, D. L., ed.; Academic Press: San Diego, 1996, pp.
291-334. "Mechanism-Based Enzyme Inactivators."
139. Lu, X.; Yang, S.; Silverman, R.B. J. Org. Chem., 1996, 61, 8961-8966. "Monoamine Oxidase-Catalyzed Oxidative Rearrangement
of trans, trans-1-(Aminomethyl)-2-methoxy-3-phenylcyclopropane."
140a. Silverman, R. B.; Lu, X.; Blomquist, G.; Ding, C. Z.; Yang, S. Bioorg. Med. Chem. 1997,5, 297-304. "Inactivation of
Monoamine Oxidase B by Benzyl 1-(Aminomethyl)cyclopropane-1-carboxylate."
140b. Silverman, R. B.; Lu, X.; Blomquist, G.; Ding, C. Z.; Yang, S. Bioorg. Med. Chem. 1998,6, 365. Corrigendum to "Inactivation
of Monoamine Oxidase B by Benzyl 1-(Aminomethyl)cyclopropane-1-carboxylate."
141. Zhou, J. P.; Li, J.; Upadhyaya, S.; Eaton, P. E.; Silverman, R. B. J. Med. Chem. 1997, 40, 1165-1168. "4-Substituted
Cubylcarbinyl Amines: A New Class of Mechanism-Based Monoamine Oxidase B Inactivators."
142. Silverman, R. B. Il Farmaco, 1997, 52, 343-352. "Oxazolidinones, Dihydrofuranones, and Pyrrolidinones as Inactivators and Substrates
of Monoamine Oxidase B: Approaches to the Design of Antiparkinsonian Agents."
143. Fast, W.; Levsky, M. E.; Marletta, M. A.; Silverman, R. B., Bioorg. Med. Chem. 1997, 5, 1601-1608. "Nω-Propargyl-L-arginine
and Nω-Hydroxy-Nω-propargyl-L-arginine are Inhibitors, but Not Inactivators, of Neuronal and Macrophage Nitric Oxide Synthases."
144. Fast, W.; Huff, M. E.; Silverman, R. B. Bioorg. Med. Chem. Lett. 1997, 7, 1449-1454. "Time-Dependent Inhibition of Neuronal
Nitric Oxide Synthase by N-Propargylguanidine."
145. Zhong, B.; Silverman, R. B. J. Am. Chem. Soc. 1997, 119, 6690-6691. "Identification of the Active Site Cysteine in Bovine Liver
Monoamine Oxidase B."
146. Silverman, R. B.; Huang, H.; Marletta, M. A.; Martasek, P. J. Med. Chem. 1997, 40, 2813-2817. "Selective Inhibition of Neuronal Nitric Oxide
Synthase by Nω-Nitroarginine- and Phenylalanine-Containing Dipeptides and Dipeptide Esters."
147. Zhang, H. Q.; Dixon, R. P.; Marletta, M. A.; Nikolic, D.; Van Breemen, R.; Silverman, R. B., J. Am Chem. Soc. 1997, 119, 10888-10902. "Mechanism of Inactivation of Neuronal Nitric Oxide Synthase
by Nω-Allyl-L-arginine."
148. Zhang, H. Q.; Fast, W.; Marletta, M. A.; Martasek, P.; Silverman, R. B. J. Med. Chem. 1997, 40, 3869-3870. "Potent
and Selective Inhibition of Neuronal Nitric Oxide Synthase by Nω-Propyl-L-arginine."
149. Olson, G. T.; Fu, M.; Lau, S.; Rinehart, K. L.; Silverman, R. B., J. Am. Chem. Soc. 1998, 120, 2256-2267. "An Aromatization
Mechanism of Inactivation of γ-Aminobutyric Acid Aminotransferase for the Antibiotic L-Cycloserine."
150. Yelekçi, K.; Silverman, R. B., J. Enzyme Inhib. 1998, 13, 31-39. "Effect of the Locus of the Oxygen Atom in Amino Ethers
on the Inactivation of Monoamine Oxidase B."
151. Lu, X.; Silverman, R. B. Bioorg. Med. Chem. 1998, 6, 1851-1856. "Inactivation of Monoamine Oxidase B by cis- and
trans-5-Aminomethyl-3-(4-methoxyphenyl)dihydrofuran-2(3H)-ones."
152. Lu, X.; Silverman, R. B. J. Am. Chem. Soc. 1998, 120, 10583-10587. "Monoamine Oxidase B-Catalyzed Reactions of cis- and trans-5-Aminomethyl-3-(4-methoxyphenyl)dihydrofuran-2(3H)-ones.
Evidence for a Reversible Redox Reaction."
153. Wang, X.; Silverman, R. B. J. Org. Chem. 1998, 63, 7357-7363. "2-(Iodoethenyl)benzyl Amines as Potential Probes for Radical
Intermediates Formed During Monoamine Oxidase-Catalyzed Oxidations."
154. Zhong, B.; Lu, X.; Silverman, R. B. Bioorg. Med. Chem. 1998, 6, 2405-2419. "Syntheses of Amino Nitrones. Potential Intramolecular
Traps for Radical Intermediates in Monoamine Oxidase-Catalyzed Reactions."
155. Fast, W.; Nikolic, D.; Van Breemen, R.; Silverman, R. B. J. Am. Chem. Soc. 1999, 121, 903-916. "Mechanism of Inactivation of Inducible
Nitric Oxide Synthase by N5-(1-Iminoethyl)-L-ornithine (L-NIO)."
156. Lee, Y.; Marletta, M. A.; Martasek, P.; Roman, L. J.; Masters, B. S. S.; Silverman, R. B. Bioorg. Med. Chem., 1999, 7, 1097-1104. "Conformationally-restricted Arginine Analogues as Alternative
Substrates and Inhibitors of Nitric Oxide Synthases."
157. Qiu, J.; Stevenson, S. H.; O'Beirne, M. J.; Silverman, R. B. J. Med. Chem. 1999, 42, 329-332. "2,6-Difluorophenol as a
Bioisostere of a Carboxylic Acid: Bioisosteric Analogues of γ-Aminobutyric Acid."
158. Tierney, D. L.; Huang, H.; Martasek, P.; Masters, B. S. S.; Silverman, R. B.; Hoffman, B. M. Biochemistry 1999, 38,
3704-3710. "ENDOR Spectroscopic Evidence for the Position and Structure of NG-Hydroxy-L-arginine
Bound to holo-Neuronal Nitric Oxide Synthase."
159. Johnson, T. R.; Silverman, R. B. Bioorg. Med. Chem. 1999, 7, 1625-1636. "Syntheses of (Z)- and (E)-4-Amino-2-(trifluoromethyl)-2-butenoic
Acid and Their Inactivation of γ-Aminobutyric Acid Aminotransferase."
160. Fu, M.; Silverman, R. B. Bioorg. Med. Chem. 1999, 7, 1581-1590. "Isolation and Characterization of the Product of Inactivation
of γ-Aminobutyric Acid Aminotransferase by Gabaculine."
161. Huang, H.; Martasek, P.; Roman, L. J.; Masters, B. S. S.; Silverman, R. B. J. Med. Chem. 1999, 42, 3147-3153. "Nω-Nitroarginine-Containing
Dipeptide Amides. Potent and Highly Selective Inhibitors of Neuronal Nitric Oxide Synthase."
162. Lee, Y.; Martasek, P.; Roman, L. J.; Masters, B. S. S.; Silverman, R. B. Bioorg. Med. Chem. 1999, 7, 1941-1951. "Imidazole-Containing
Amino Acids as Selective Inhibitors of Nitric Oxide Synthases."
163. Lee, Y.; Silverman, R. B. Synthesis 1999, 1495-1499. "Solid-Phase Syntheses of Nω-Propylarginine-Containing
Dipeptides, Dipeptide Esters, and Dipeptide Amides."
164. Fu, M.; Nikolic, D.; Van Breemen, R.; Silverman, R. B. J. Am. Chem. Soc. 1999, 121, 7751-7759. "Mechanism of Inactivation
of γ-Aminobutyric Acid Aminotransferase by (S)-4-Amino-4,5-dihydro-2-thiophenecarboxylic Acid."
165. Lee, Y.; Silverman, R. B. J. Am. Chem. Soc. 1999, 121, 8407-8408. "Efficient Solid-Phase Synthesis of Compounds Containing
Phenylalanine and its Derivatives via Side-Chain Attachment to the Polymer Support."
166. Qiu, J.; Pingsterhaus, J. M.; Silverman, R. B. J. Med. Chem. 1999, 42, 4725-4728. "Inhibition and Substrate Activity of Conformationally-Rigid
Vigabatrin Analogues with γ-Aminobutyric Acid Aminotransferase."
167. Woodroofe, C. C.; Mostashari, R.; Lu, X.; Ramsay, R. R.; Silverman, R. B. J. Enzyme Inhib. 1999, 15, 11-21. "Selective
Inhibition of Monoamine Oxidase B by Aminoethyl Substituted Benzyl Ethers."
168. Chebib, M.; Johnston, G. A. R.; Mattsson, J. P.; Rydström, K., Nilsson, K.; Qiu, J.; Stevenson, S. H.; Silverman, R. B. Bioorg. Med. Chem. Lett.
1999, 9, 3093-3098. "Aminomethyl-2,6-difluorophenols
as a Novel Class of Increased Lipophilicity GABAC Receptor Antagonists."
169. Tantillo, D.; Fukuto, J. M.; Hoffman, B. M.; Silverman, R. B.; Houk, K. N. J. Am. Chem. Soc. 2000, 122, 536-537. "Theoretical
Studies on NG-Hydroxy-L-arginine and Derived Radicals: Implications for the Mechanism of Nitric Oxide Synthase."
170. Koo, Y. K.; Nandi, D.; Silverman, R. B. Arch. Biochem. Biophys. 2000, 374, 248-254. "Multiple Active Enzyme Species of
γ-Aminobutyric Acid Aminotransferase are not Isozymes, but are Proteolytic Fragments."
171. Woodroofe, C. C.; Zhong, B.; Lu, X.; Silverman, R. B. J. Chem. Soc. Perkin Trans. 2 2000, 55-60. "Anomalous Schmidt Reaction
Products of Phenylacetic Acid and Derivatives."
172. Qiu, J.; Silverman, R. B. J. Med. Chem. 2000, 43, 706-720. "A New Class of Conformationally-Rigid Analogues of 4-Amino-5-halopentanoic
Acids, Potent Inactivators of γ-Aminobutyric Acid Aminotransferase."
173. Lee, Y.; Silverman, R. B. Organic Lett. 2000, 2, 303-306. "Traceless Solid-Phase Synthesis of Chiral 3-Aryl β-Amino Acid-Containing
Peptides Using a Side Chain Tethered β-Amino Acid Building Block."
174. Wang, X.; Silverman, R. B. Bioorg. Med. Chem. 2000, 8, 1645-1651. "Monoamine Oxidase-Catalyzed Oxidation of endo,
endo-2-Amino-6-[(Z)-2'-phenyl]ethenylbicyclo[2.2.1]heptane, a Potential Probe for a Radical Cation Intermediate."
175. Tierney, D. L.; Huang, H.; Martásek, P.; Roman, L. J.; Silverman, R. B.; Masters, B. S. S.; Hoffman, B. M. J. Am. Chem. Soc.
2000, 122, 5405-5406. "ENDOR Studies of L-Arginine and NG-Hydroxy-L-Arginine Bound to All Three Holo-Nitric Oxide
Synthase Isozymes."
176. Huang, H.; Martásek, P.; Roman, L. J.; Silverman, R. B. J. Med. Chem. 2000, 43, 2938-2945. "Synthesis and Evaluation of Peptidomimetics
as Selective Inhibitors and Active Site Probes of Nitric Oxide Synthases."
177. Tierney, D. L.; Huang, H.; Martásek, P.; Roman, L. J.; Silverman, R. B.; Hoffman, B. M. J. Am. Chem. Soc. 2000, 122, 7869-7875.
"ENDOR Spectroscopic Evidence for the Geometry of Binding of retro-inverso-Nω-Nitroarginine-Containing Dipeptide Amides
to Neuronal Nitric Oxide Synthase."
178. Hah, J. M.; Roman, L. J.; Silverman, R. B. Bioorg. Med. Chem. 2000, 8, 1931-1936. "Deuterium Isotope Effects and Product Studies for the Oxidation of
Nω-Allyl-L-arginine and Nω-Allyl-Nω-hydroxy-L-arginine by Neuronal Nitric Oxide Synthase."
179. Lee, Y.; Silverman, R. B. Organic Lett. 2000, 2, 3743-3746. "Rapid, High-Yield, Solid-Phase Synthesis
of the Antitumor Antibiotic Sansalvamide A Using a Side-Chain-Tethered Phenylalanine Building Block."
180. Lee, Y.; Martásek, P.; Roman, L. J.; Silverman, R. B. Bioorg. Med. Chem. Lett. 2000, 10, 2771-2774 "1-H-Pyrazole-1-carboxamidines: New Inhibitors of Nitric
Oxide Synthase."
181. Mitchell, D. J.; Nikolic, D.; Rivera, E.; Sablin, S. O.; Choi, S.; van Breemen, R. B.; Singer, T. P.; Silverman, R. B. Biochemistry 2001, 40, 5447-5456. "Spectrometric
Evidence for the Flavin-1-phenylcyclopropylamine Inactivator Adduct with Monoamine Oxidase N."
182. Huang, H.; Martásek, P.; Roman, L. J.; Silverman, R. B. J. Enzyme Inhib. 2001, 16, 233-239. "Synthesis and Evaluation of Dipeptide Amides Containing Nω-Nitroarginine
and D-2,4-Diaminobutyric Acid as Inhibitors of Neuronal Nitric Oxide Synthase."
183. Huang, H.; Hah, J.-M.; Silverman, R. B. J. Am. Chem. Soc. 2001, 123, 2674-2676. "Mechanism of Nitric Oxide Synthase.
Evidence that Direct Hydrogen Atom Abstraction from the O-H Bond of NG-Hydroxyarginine is Not Relevant to the Mechanism."
184. Mitchell, D. J.; Nikolic, D.; van Breemen, R. B.; Silverman, R. B. Bioorg. Med. Chem. Lett., 2001, 11,
1757-1760. "Inactivation of Monoamine Oxidase B by 1-Phenylcyclopropylamine: Mass Spectral Evidence for the Flavin Adduct."
185. Mitchell, D. J.; Nikolic, D.; Jang, M.-H.; van Breemen, R. B.; Hille, R.; Silverman, R. B. Biochemistry 2001, 40, 8523-8530. "Inactivation of C30A Trimethylamine
Dehydrogenase by N-Cyclopropyl-α-methylbenzylamine, 1-Phenylcyclopropylamine, and Phenylhydrazine."
186. Lee, Y.; Silverman, R. B. Tetrahedron 2001, 57, 5339-5352. "Silicon-Based Aromatic Transferring Linkers for Traceless Solid-Phase Synthesis of Aryl-, Polyaryl-,
and Heteroaryl-Containing Compounds."
187. Hah, J.-M.; Roman, L. J.; Martásek, P.; Silverman, R. B. J. Med. Chem. 2001, 44, 2667-2670. "Reduced Amide Bond
Peptidomimetics. (4S)-N-(4-Amino-5-[aminoalkyl]aminopentyl)-N'-nitroguanidines, Potent and Highly Selective Inhibitors of Neuronal Nitric Oxide
Synthase."
188. Gómez-Vidal, J. A.; Forrester, M. T.; Silverman, R. B. Organic Lett. 2001, 3, 2477-2479. "Mild
and Selective Sodium Azide-Mediated Cleavage of p-Nitrobenzoic Esters."
189. Gómez-Vidal, J. A.; Silverman, R. B. Organic Lett. 2001, 3, 2481-2484. "Short, Highly Efficient Syntheses of 3-Azido- and 4-Azidoproline Derivatives and Their
Precursors."
190. Choi, S.; Storici, P.; Schirmer, T.; Silverman, R. B. J. Am. Chem. Soc. 2002, 124, 1620-1624. "Design of a Conformationally-Restricted
Analogue of the Antiepilepsy Drug Vigabatrin that Directs its Mechanism of Inactivation of γ-Aminobutyric Acid Aminotransferase."
191. Choi, S.; Silverman, R. B. J. Med. Chem. 2002, 45, 4531-4539. "Inactivation and Inhibition of γ-Aminobutyric Acid Aminotransferase by Conformationally-Restricted
Vigabatrin Analogues."
192. Lu, X.; Rodriguez, M.; Ji, H.; Silverman, R. B.; Vintém, A. P. B.; Ramsay, R. R. "Irreversible Inactivation of Mitochondrial Monoamine
Oxidases" In Flavins and Flavoproteins 2002: Proceedings of the 14th International Symposium; Chapman, S. K.; Perham,
R. N.; Scrutton, N. S., Eds.; Rudolf Weber: Berlin, Germany, 2002; pp 817-830.
193. Gu, W.; Liu, S.; Silverman, R. B. Organic Lett. 2002, 4, 4171-4174. "Solid-Phase, Pd-Catalyzed, Silicon-Aryl Carbon Bond Formation.
Synthesis of Sansalvamide A Peptide."
194. Lee, Y.; Ling, K.-Q.; Lu, X.; Silverman, R. B.; Shepard, E. M.; Dooley, D. M.; Sayre, L. M. J. Am. Chem. Soc. 2002, 124, 12135-12143.
"3-Pyrrolines are Mechanism-Based Inactivators of the Quinone-Dependent Amine Oxidases but Only Substrates of the Flavin-Dependent Amine Oxidases."
195. Nandi, D.; Lightcap, E. S.; Koo, Y. K.; Lu, X.; Quancard, J.; Silverman, R. B. Int. J. Biochem. Cell Biol., 2003, 35, 1085-1097. "Purification
and Inactivation of 3-Hydroxyanthranilic Acid 3,4-Dioxygenase from Beef Liver."
196. Gu, W.; Silverman, R. B. Organic Lett. 2003, 5, 415-418. "New Stable Backbone Linker Resins for Solid-Phase Peptide Synthesis."
197. Hah, J.-M.; Martásek, P.; Roman, L. J.; Silverman, R. B. J. Med. Chem. 2003, 46, 1661-1669."Aromatic Reduced Amide Bond Peptidomimetics
as Selective Inhibitors of Neuronal Nitric Oxide Synthase."
198. Lu, X.; Rodríguez, M.; Gu, W.; Silverman, R. B. Bioorg. Med. Chem. 2003, 11, 4423-4430. "Inactivation of Mitochondrial Monoamine Oxidase
B by Methylthio-Substituted Benzylamines."
199. Lu, X.; Nikolic, D.; Mitchell, D. J.; van Breemen, R. B.; Mersfelder, J. A.; Hille, R.; Silverman, R. B. Bioorg. Med. Chem. Lett. 2003, 13, 4129-4132 . "A Mechanism for Substrate-Induced
Formation of 6-Hydroxyflavin Mononucleotide Catalyzed by C30A Trimethylamine Dehydrogenase."
200. Gu, W.; Silverman, R. B. J. Org. Chem. 2003, 68, 8774-8779. "Solid-Phase Total Synthesis of Scytalidamide A."
201. Ji, H.; Li, H.; Flinspach, M.; Poulos, T. L.; Silverman, R. B. J. Med. Chem., 2003, 46, 5700-5711. "Computer Modeling of
Selective Regions in the Active Site of Nitric Oxide Synthases: Implication for the Design of Isoform-Selective Inhibitors."
202. Pan, Y.; Qiu, J.; Silverman, R. B. J. Med. Chem. 2003, 46, 5292-5293. "Design, Synthesis, and Biological Activity of
a Difluoro-substituted, Conformationally-rigid Vigabatrin Analogue As a Potent γ-Aminobutyric Acid Aminotransferase Inhibitor."
203. Flinspach, M.; Li, H.; Jamal, J.; Yang, W.; Huang, H.; Hah, J.-M.; Gomez-Vidal, J. A.; Litzinger, E. A.; Silverman, R. B.; Poulos, T. L. Nature
(Struct. Mol. Biol.) 2004, 11, 54-59. "Structural Basis for Dipeptide Amide Isoform-Selective Inhibition of Neuronal
Nitric Oxide Synthase."
204. Fu, M.; Silverman, R. B. Bioorg. Med. Chem. Lett. 2004, 14, 203-206. "Inactivation of γ-Aminobutyric Acid Aminotransferase
by (S)-4-Amino-4,5-dihydro-2-furancarboxylic Acid Does Not Proceed by the Expected Aromatization Mechanism."
205. Storici, P.; De Biase, D.; Bossa, F.; Bruno, S.; Mozzarelli, A.; Peneff, C.; Silverman, R. B.; Schirmer, T. J. Biol. Chem. 2004, 279, 363-373. "Structures of GABA Aminotransferase,
a Pyridoxal 5'-Phosphate and [2Fe-2S] Cluster Containing Enzyme, Complexed with the Antiepilepsy Drug Vigabatrin and with γ-Ethynyl GABA."
206. Gómez-Vidal, J. A.; Martásek, P.; Roman, L. J.; Silverman, R. B. J. Med. Chem. 2004, 47, 703-710. "Potent and Selective Conformationally-Restricted Neuronal Nitric Oxide
Synthase Inhibitors."
207. Wang, Z.; Silverman, R. B. J. Enz. Inhib. Med. Chem. 2004, 19, 293-301. "Synthesis of Cyclopropane Isosteres of the
Antiepilepsy Drug Vigabatrin and Evaluation of their Inhibition of GABA Aminotransferase."
208. Flinspach, M.; Li, H.; Jamal, J.; Yang, W.; Huang, H.; Silverman, R. B.; Poulos, T. L. Biochemistry 2004, 43,
5181-5187. "Structures of the Neuronal and Endothelial NOS Heme Domain with D-Nitroarginine-containing Dipeptide Inhibitors Bound."
209. Schering, C. A.; Zhong, B.; Woo, J. C. G.; Silverman, R. B. Bioconj. Chem. 2004, 15, 673-676. "Poly(ethylene glycol)-Supported Enzyme Inactivators.
Efficient Identification of the Site of Covalent Attachment to α-Chymotrypsin by PEG-TPCK."
210. Pan, Y.; Calvert, K.; Silverman, R. B. Bioorg. Med. Chem. 2004, 12, 5719-5725. "Conformationally-Restricted Vigabatrin Analogues as
Irreversible and Reversible Inhibiors of γ-Aminobutyric Acid Aminotransferase."
211. Storici, P.; Qiu, J.; Schirmer, T.; Silverman, R. B. Biochemistry 2004, 43, 14057-14063. "Mechanistic Crystallography. Mechanism of Inactivation
of γ-Aminobutyric Acid Aminotransferase by (1R,3S,4S)-3-Amino-4-fluorocyclopentane-1-carboxylic Acid as Elucidated by Crystallography."
212. Westerheide, S. D.; Bosman, J. D.; Mbadugha, B. N. A.; Kawahara, T. L. A.; Matsumoto, G.; Gu, W.; Kim, S.; Devlin, J. P.; Silverman, R. B.; Morimoto, R. I.
J. Biol. Chem. 2004, 279, 56053-56060. "Celastrols as Inducers of the Heat Shock Response and Cytoprotection."
213. Zhu, Y.; Nikolic, D.; Van Breemen, R. B.; Silverman, R. B. J. Am. Chem. Soc. 2005, 127, 858-868. "Mechanism of Inactivation of Inducible Nitric Oxide Synthase
by Amidines. Irreversible Enzyme Inactivation without Inactivator Modification."
214. Erdal, E. P.; Litzinger, E. A.; Seo, J.; Zhu, Y.; Ji, H.; Silverman, R. B. Curr. Topics Med. Chem. 2005, 5, 603-624. "Selective
Neuronal Nitric Oxide Synthase Inhibitors."
215. Vintém, A. P. B.; Price, N. T.; Silverman, R. B.; Ramsay, R. R. Bioorg. Med. Chem. 2005, 13, 3487-3495. "Mutation of Surface
Cysteine 374 to Alanine in Monoamine Oxidase A Alters Substrate Turnover and Inactivation by Cyclopropylamines."
216. Liu, S.; Gu, W.; Lo, D.; Ding, X.-Z.; Ujiki, M.; Adrian, T. E.; Soff, G. A.; Silverman, R. B. J. Med. Chem. 2005, 48, 3630-3638. "N-
Methylsansalvamide A Peptide Analogues. Potent New Antitumor Agents."
217. Li, H.; Flinspach, M. L.; Igarashi, J.; Jamal, J.; Yang, W.; Gomez-Vidal, J. A.; Litzinger, E. A.; Huang, H.; Erdal, E. P.; Silverman, R. B.; Poulos, T. L.
Biochemistry 2005, 44, 15222-15229. "Exploring the Binding Conformations of Bulkier Dipeptide Amide Inhibitors in
Constitutive Nitric Oxide Synthases."
218. Crittenden, D. L.; Park, A.; Qiu, J.; Silverman, R. B.; Duke, R. K.; Johnston, G. A. R.; Jordan, M. J. T.; Chebib, M. Bioorg. Med. Chem.
2006, 14, 447-455. "Enantiomers of cis-constrained and flexible 2-substituted GABA analogues exert opposite effects at
recombinant GABAC receptors."
219. Yuan, H.; Silverman, R. B. Bioorg. Med. Chem. 2006, 14, 1331-1338. "New Substrates and Inhibitors of γ-Aminobutyric
Acid Aminotransferase Containing Bioisosteres of the Carboxylic Acid Group: Design, Synthesis, and Biological Activity."
220. Ujiki, M. B.; Milam, B.; Ding, X.-Z.; Roginsky, A. B.; Salabat, M. R.; Talamonti, M. S.; Bell, R. H.; Gu, W.; Silverman, R. B.; Adrian, T. E. Biochem. Biophys.
Res. Commun. 2006, 340, 1224-1228. "A Novel Peptide Sansalvamide A Analogue Inhibits Pancreatic Cancer Cell Growth Through G0/G1
Cell Cycle Arrest."
221. Wang, Z.; Silverman, R. B. Biochemistry 2006, 14, 2242-2252. "Syntheses and Evaluation of Fluorinated Conformationally
Restricted Analogues of GABA as Potential Inhibitors of GABA Aminotransferase."
222. Litzinger, E. A.; Martásek, P.; Roman, L. J.; Silverman, R. B. Bioorg. Med. Chem. 2006, 14, 3185-3198. "Design, Synthesis, and Biological Testing of
Potential Heme-Coordinating Nitric Oxide Synthase Inhibitors."
223. Gu, W.; Nusinzon, I.; Smith, R. D. Jr.; Horvath, C. M.; Silverman, R. B. Bioorg. Med. Chem. 2006, 14, 3320-3329.
"Carbonyl- and Sulfur-Containing Analogs of Suberoylanilide Hydroxamic Acid. Potent Inhibition of Histone Deacetylases."
224. Mbadugha, B. N. A.; Seo, J.; Ji, H.; Martásek, P.; Roman, L. J.; Shea, T. M.; Silverman, R. B. Bioorg. Med. Chem. 2006, 14, 3681-3690.
"Hydroxyl-terminated Peptidomimetic Inhibitors of Neuronal Nitric Oxide Synthase."
225. Seo, J.; Silverman, R. B. Tetrahedron Lett., 2006, 47, 4069-4073.
"Synthesis of Arginine-containing Hydroxamate Dipeptidomimetics."
226. Lawton, G. L.; Ji, H.; Silverman, R. B. Tetrahedron Lett., 2006, 47, 6113-6115. "Remote Protection Prevents Unwanted Cyclizations with
2-Aminopyridines."
227. Ji, H.; Gómez-Vidal, J. A.; Martásek, P.; J. Roman, L. J.; Silverman, R. B. J. Med. Chem., 2006, 49,
6254-6263. "Conformationally-Restricted Dipeptide Amides as Potent and Selective Neuronal Nitric Oxide Synthase Inhibitors."
228. Lu, H.; Silverman, R. B. J. Med. Chem., 2006, 49, 7404-7412. "Fluorinated Conformationally-Restricted γ-Aminobutyric Acid Aminotransferase Inhibitors."
229. Wang, Z.; Yuan, H.; Silverman, R. B. Biochemistry, 2006, 45, 14513-14522. "(±)-(1S,2R,5S)-5-Amino-2-fluorocyclohex-3-ene Carboxylic Acid, A Potent GABA Aminotransferase Inactivator
that Irreversibly Inhibits through an Elimination-Aromatization Pathway."
230. Zhu, Y.; Silverman, R. B. J. Org. Chem., 2007, 72, 233-239. "Electronic Effects of Peripheral Substituents on Porphyrin Meso-Positions."
231. Seo, J.; Igarashi, J.; Li, H.; Martásek, P.; Roman, L. J.; Poulos, T. L.; Silverman, R. B. J. Med. Chem. 2007, 50, 2089-2099. "Structure-Based Design and Synthesis of Nw-Nitro-L-Arginine-Containing Peptidomimetics as Selective Inhibitors of Neuronal Nitric Oxide Synthase. Displacement of the Heme Structural Water."
232. Seo, J.; Martásek, P.; Roman, L. J.; Silverman, R. B. Bioorg. Med. Chem. 2007, 15, 1928-1938. "Selective L-Nitroargininylaminopyrrolidine and L-Nitroargininylaminopiperidine Neuronal Nitric Oxide Synthase Inhibitors."
233. Yuan, H.; Silverman, R. B. Bioorg. Med. Chem. Lett. 2007, 17, 1651-1654."Structural Modifications of (1S,3S)-3-Amino-4-Difluoromethylenecyclopentanecarboxylic Acid, a Potent Irreversible Inhibitor of GABA Aminotransferase."
234. Zhu, Y.; Silverman, R. B. Org. Lett. 2007, 9, 1195-1198. "Model Studies for Heme Oxygenase-Catalyzed Porphyrin Meso Hydroxylation."
235. Gu, W.; Cueto, M.; Jensen, P. R.; Fenical, W.; Silverman, R. B. Tetrahedron 2007, 63, 6535-6541. "Microsporins A and B: new histone deacetylase inhibitors from the marine-derived fungus Microsporum cf. gypseum and the solid-phase synthesis of microsporin A."
236. Erdal, E. P.; Martásek, P.; Linda J. Roman, L. J.; Silverman, R. B. Bioorg. Med. Chem. 2007, 15, 6096-6108. "Hydroxyethylene Isosteres of Selective Neuronal Nitric Oxide Synthase Inhibitors."
237. Clift, M.; Ji, H.; Deniau, G. P.; O’Hagan, D.; Silverman, R. B. Biochemistry 2007, 46(48), 13819-13828. "The Enantiomers of 4-Amino-3-fluorobutanoic Acid as Substrates for g-Aminobutyric Acid Aminotransferase. Conformational Probes for GABA Binding."
238. Silverman, R. B. Angew. Chem. Int. Ed. 2008, 47, 3500-3504. "From Basic Science to Blockbuster Drug. The Discovery of Lyrica."
239. Clift, M. D.; Silverman, R. B. Bioorg. Med. Chem. Lett. 2008, 18 (10), 3122-3125. "Synthesis and Evaluation of Novel Aromatic Substrates and Competitive Inhibitors of GABA Aminotransferase."
240. Ji, H.; Stanton, B. Z.; Igarashi, J.;, Li, H.; Martásek, P.; Roman, L. J.; Poulos, T. L.; Silverman, R. B. J. Am. Chem. Soc. 2008, 130(12), 3900-3914. "Minimal Pharmacophoric Elements and Fragment Hopping, an Approach Directed at Molecular Diversity and Isozyme Selectivity. Design of Selective Neuronal Nitric Oxide Synthase Inhibitors."
241. Zhu, Y.; Silverman, R. B. Biochemistry 2008, 47(8), 2231-2243. "Revisiting Heme Mechanisms. A Perspective on the Mechanisms of Nitric Oxide Synthase (NOS), Heme Oxygenase (HO), and Cytochrome P450s (CYP450s)."
242. Trott, A.; West, J. D.; Klaic, L.; Westerheide, S. D.; Silverman, R. B.; Morimoto, R. I.; Morano, K. A. Mol. Biol. Cell 2008, 19(3), 1104-1112. "Activation of Heat Shock and Antioxidant Responses by the Natural Product Celastrol: Transcriptional Signatures of a Thiol-targeted Molecule."
243. Silverman, R. B., Enzyme Inhibition In Wiley Encyclopedia of Chemical Biology; John Wiley & Sons, Hoboken, 2009, Volume 1, pp 663-681.
244. Ji,H.; Tan,S.; Igarashi,J.; Li,H.; Derrick,M.; Martásek,P.; Roman,L. J.; Vásquez-Vivar,J.; Poulos,T. L.; Silverman, R. B. Ann. Neurol. 2009, 65, 209-217. "Selective Neuronal Nitric Oxide Synthase Inhibitors for Prevention of Cerebral Palsy."
245. Ji, H.; Erdal, E. P.; Litzinger, E. A.; Seo, J.; Zhu, Y.; Xue, F.; Fang, J.; Huang, J.; Silverman, R. B. Frontiers in Medicinal Chemistry, Reitz, A. B.; Choudhary, M. I.; Atta-ur-Rahman, Editors; Bentham Science Publishers, Volume 5, 2009, 842-882. "Selective Neuronal Nitric Oxide Synthase Inhibitors."
246. Ji,H.; Li, H.; Martásek, P.; Roman, L. J.; Poulos, T. L.; Silverman, R. B. J. Med. Chem. 2009, 52 (3), 779–797. " Discovery of Highly Potent and Selective Inhibitors of Neuronal Nitric Oxide Synthase by Fragment Hopping."
247. Silverman, R. B. Acc. Chem. Res. 2009, 42, 439-451. " Design of Selective Neuronal Nitric Oxide Synthase Inhibitors for the Prevention and Treatment of Neurodegenerative Diseases."
248. Igarashi, J.; Li, H.; Jamal, J.; Ji, H.; Fang, J.; Lawton, G. R.; Silverman, R. B.; Poulos, T. L. J. Med. Chem. 2009, 52, 2060-2066. "Crystal Structures of Constitutive Nitric Oxide Synthases in Complex with De Novo Designed Inhibitors."
249. Lawton, G. R.;Ralay Ranaivo, H.; Wing, L. K.; Ji, H.; Xue, F.; Martásek, P.; Roman, L. J.; Watterson, D. M.; Silverman, R. B. Bioorg. Med. Chem. 2009, 17(6), 2371-2380. " Analogues of 2-aminopyridine-based Selective Inhibitors of Neuronal Nitric Oxide Synthase with Increased Bioavailability."
250. Fang, J.; Ji,H.; Lawton, G. R.; Xue, F.; Martásek, P.; Roman, L. J.; Silverman, R. B. J. Med. Chem. 2009, 52, 4533-4537. "L337H Mutant of Rat Neuronal Nitric Oxide Synthase Resembles Human Neuronal Nitric Oxide Synthase Toward Inhibitors."
251. Fang, J.; Silverman, R. B. Anal. Biochem. 2009, 390, 74-78. "A Cellular Model for Screening Neuronal Nitric Oxide Synthase Inhibitors."
252. Lawton, G. R.; Ji,H.; Martásek, P.; Roman, L. J.; Silverman, R. B. Beilstein J. Org. Chem. 2009, 5, No. 28. "Synthesis and Enzymatic Evaluation of 2- and 4-aminothiazole-based Inhibitors of Neuronal Nitric Oxide Synthase."
253. Derrick, M.; Drobyshevsky, A.; Ji, X.; Chen, L.; Yang, Y.; Ji, H.; Silverman, R. B.; Tan, S.
Int. J. Devel. Neurosci. 2009, in press. "Hypoxia-ischemia causes persistent movement deficits in a perinatal rabbit model of cerebral palsy: assessed by a new swim test."
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