KARL A. SCHEIDT
Irving M. Klotz Professor
Department
of Chemistry, Northwestern University
2145
Sheridan Road, Evanston, IL 60208
scheidt@northwestern.edu, 847-491-6659
Education
Ph.D. in Organic Chemistry. Indiana University, Bloomington, Indiana. 1999
B.S. in Chemistry. University of Notre Dame, Notre Dame, Indiana, 1994
Professional
Experience
Northwestern University: Assistant Professor of Chemistry, 2002-2008
Northwestern University: Associate Professor of Chemistry, 2008-present
Research
Experience
Harvard University: NIH Postdoctoral Fellow with David
A. Evans, 1999-2002
Indiana University/Univ. of Michigan: Graduate Research with William R.
Roush, 1994-1999
University of Notre Dame: Undergraduate Research with Marvin
J. Miller, 1992-1994
Honors
and Awards
Irving Klotz Professor of Chemistry (2008)
GlaxoSmithKline Scholar (2008-2009)
Alfred P. Sloan Fellow (2007-2009)
Amgen Young Investigator Award (2006)
Boehringer-Ingelheim New Investigator Award in Organic Chemistry (2005)
Northwestern University Distinguished Teaching Award (2005)
3M Nontenured Faculty Award (2005)
Abbott Laboratories New Faculty Award (2005)
Amgen New Faculty Award (2004)
National Science Foundation CAREER Award (2004-2008)
Northwestern University Searle Fellow (2003)
National Institutes of Health Postdoctoral Fellowship, Harvard
University (1999-2001)
Merck Award, University of Notre Dame (1994)
Research
Accomplishments to Date
Discovered new nucleophile-catalyzed carbonyl anion reactions using
acylsilanes or a-keto acids. These innovative strategies are highly versatile
and are now being applied to access unconventional bond-forming reactions with
applicability in pharmaceutical and materials research.
Discovered new carbene-catalyzed processes, including catalytic
generated homoenolates from enals and the hydroacylation of activated carbonyl
compounds. The use of N-heterocyclic carbenes as catalysts
allows efficient access to unconventional reactivity patterns with broad
application in synthesis.
Discovered copper-catalyzed disilylation of conjugate acceptors using
commercially available disilylanes activated by Lewis bases. This bimodal catalytic process
incorporates silicon effectively into various molecular architectures.
Investigating new anti-tumor natural products as potential treatments
for cancer and as tools for chemical biology. Using highly potent natural substances as the driving force
to invent new methodology, we have synthesized simplified analogs of complex
bioactive natural products to determine the key substructures necessary for
biological activity.