The research in our group comprises two complementary areas: the discovery of new reaction methodology and bioorganic chemistry. We are particularly interested in designing novel methods and strategies for the construction of complex natural products with important biological attributes. These advances in methodology reduce drastically the interval between conception of a target molecule and its synthesis. As a consequence, organic synthesis is a critical, enabling discipline that has a unique and important impact on the fields of medicine and biology.
Our methodology investigations encompass assembling molecules and introducing stereogenic centers. Specifically, we are exploring reactions that employ Lewis basic functionality (e.g. N-heterocyclic carbenes). These reactions have not received the same attention as processes employing Lewis acids and consequently, the potential of this strategy has not been realized.
Our bioorganic program focuses on the specific impact small molecules have on cellular processes. To this end, we are engaged in 1) the total synthesis of complex natural products with important bioactivity, 2) investigations into the modes of action of these unique compounds, and 3) the design and construction of potential therapeutic agents based on the molecules we synthesize.