O'Halloran Group Publications

  • Mazar AP, Ahn RW, O'Halloran TV. Development of novel therapeutics targeting the urokinase plaminogen activator receptor (uPAR) and their translation toward the clinic. Curr Pharm Des. 2011;17(19):1970-8.  PDF

  • Kim AM, Bernhardt ML, Kong BY, Ahn RW, vogt S, Woodruff TK, O'Halloran TV. Zinc sparks are triggered by fertilization and facilitate cell cycle resumption in mammalian eggs.  ACS Chem Biol. 2011 Jul 15;6(7):716-23 Epub 2011 Apr PDF

                                                       

  • Lee S-M, Lee OS, O'Halloran TV, Schatz GC, Nguyen ST. Triggered release of pharmacophores for [Ni(HAsO3)]-loaded polymer-caged nanobin enhances pro-apoptotic activity: a combine experimental and theoretical study. ACS Nano. 2011 May 24;5(5):3961-9. Epub 2011 May 9. PDF

  • Lee S-M, Song Y, Hong BJ, Macrenaris KW, Mastarone DJ, O'Halloran TV, Meade TJ, Nguyen ST. Modular polymer-caged nanobins as a theranostic platform with enhanced magnetic resonance relaxivity and pH-responsive drug release. Angew. Chem. Int. Ed. 2010 Nov 16 [Epub ahead of print].

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  • Lee S-M, O'Halloran TV, Nguyen ST. Polymer-caged nanobins for synergistic cisplatin-doxorubicin combination chemotherapy. J Am Chem Soc. 2010 Nov 15 [Epub ahead of print].

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  • Bernhardt ML, Kim AM, O'Halloran TV, Woodruff TK. Zinc requirement during meiosis I-meiosis II transition in mouse oocytes is inependent of the MOS-MAPK pathway. Biol Reprod. 2010 Nov 10. [Epub ahead of print].

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  • Lee S-M, Ahn RW, Chen F, Fought AJ, O'Halloran TV, Cryns VL, Nguyen ST. Biological evaluation of pH-responsive polymer-caged nanobins for breast cancer therapy. ACS Nano. 2010 Sep 28;4(9):4971-8.

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  • Kim AM, Vogt S, O'Halloran TV, Woodruff TK. Zinc availability regulates exit from meiosis in maturing mammalian oocytes. Nat Chem Bio. 2010 Sep;6(9):674-81. Epub 2010 Aug 8.

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  • Winter ND, Murphy RK, O'Halloran TV, Schatz GC. Development and modeling arsenic-trioxide-loaded thermosensitive liposomes for anticancer drug delivery. J Liposome Res. 2011 Jun;21(2):106-15.

  • El Muayed M., Billings, L.K., Raja M.R., Zhang X., Park P.J., Newman M.V., Kaufman D.B., O'Halloran T.V., Lowe W.L. Jr. Acute cytokine-mediated downregulation of the zinc transporter ZnT8 alters pancreatic {beta}-cell function. J Endocrinol. 2010 Aug;206(2):159-169. Epub 2010 May 27. 

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  • Ahn, R.W., Chen, F., Chen, H., Stern, S.T., Clogston, J.D., Patri, A.K., Raja, M.R., Cryns, V.L., O’Halloran, T.V. “A Novel Nanoparticulate Formulation of Arsenic Trioxide with Enhanced Therapeutic Efficacy in a Murine Model of Breast Cancer” Clin Cancer Res. 2010. Accepted for Publication May 2010.
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  • Bhalla, S., Gordon, LI, David, K., Prachand, S., Singh, A. T., Yang, S., Winter, JN, Guo, D., O'Halloran, T.V., Platanias, L., Evens, A. Glutathione depletion enhances arsenic trioxide-induced apoptosis in lymphoma cells through mitochondrial-independent mechanisims. Br J Haematol. 2010 In process.
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  • Alvarez, H.M., Xue, Y., Robinson, C.D., Canalizo-Hernández, M.A., Marvin, R.G., Kelly,R.A., Mondragón, A., Penner-Hahn, J.E., O’Halloran, T.V. Tetrathiomolybdate Inhibits Copper Trafficking Proteins Through Metal Cluster Formation. Science. 2010 Jan 327(5963):331-334.
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  • Chen, H., Pazicni, S., Krett, N.L., Ahn, R.W., Penner-Hahn, J.E., Rosen, S.T. and O’Halloran, T.V. Coencapsulation of Arsenic- and Platinum based Drugs for Targeted Cancer Treatment. Angew. Chem. Int. Ed. 2009 Nov 5;48(49):9295-9299.
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  • You EA, Ahn RW, Lee MH, Raja MR, O'Halloran T.V., Odom TW. Size Control of Arsenic Trioxide Nanocrystals Grown in Nanowells. J. Amer. Chem. Soc. 2009 131 (31):10863-5.
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  • Lee SM, Chen H, O'Halloran T.V., Nguyen SBT. Clickable' Polymer-Caged Nanobins as a Modular drug Delivery Platform. J. Amer. Chem. Soc. 2009 131(26):9311-20.
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  • Chen H, Ahn R, Van den Bossche J, Thompson DH, O’Halloran T.V. Folate-mediated Intracellular Drug Delivery Increases the Anti-cancer Efficacy of Nanoparticulate Formulation of Arsenic Trioxide.  Molecular Cancer Therapeutics. 2009 8(7):1955-63.
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  • Furukawa Y, Kaneko K, Yamanaka K, O'Halloran T.V., Nukina N. Complete Loss of Post-translational Modifications Triggers Fibrillar Aggregation of SOD1 in the Familial Form of Amyotrophic Lateral Sclerosis. J Biol Chem. 2008  283(35):24167-76.
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  • Davis, A.V., O'Halloran, T.V. "A place for thioether chemistry in cellular copper ion recognition and trafficking." Nature Chemical Biology, 2008, 4, 148-151.
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  • Chen, H., MacDonald, R.C., Li, S., Krett, N.L., Rosen, S.T., O'Halloran, T.V. "Lipid encapsulation of arsenic trioxide attenuates cytotoxicity and allows for controlled anticancer drug release." J. Amer. Chem. Soc., 2006, 128, 13348-13349.
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  • Culotta, V.C., Yang, M., O'Halloran, T.V. "Activation of Superoxide Dismutases: Putting the Metal to the Pedal." Biochim. Biophys. Acta, 2006, 1763, 747-758.
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  • Furukawa, Y., O'Halloran, T.V. "Posttranslational modifications in Cu,Zn-superoxide dismutase and mutations associated with amyotrophic lateral sclerosis." Antiox. Redox. Signal., 2006, 8, 847-867.
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  • Deng, H.X., Shi, Y., Furukawa, Y., Zhai, H., Fu, R., Liu, E., Gorrie, G.H., Khan, M.S., Hung, W.Y., Bigio, E.H., Lukas T., Dal Canto, M.C., O'Halloran, T.V., Siddique, T. "Conversion to the amyotrophic lateral sclerosis phenotype is associated with intermolecular linked insoluble aggregates of SOD1 in mitochondria." Proc. Natl. Acad. Sci, 2006, 103, 7142-7147.
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  • Furukawa, Y., Fu, R., Deng, H.X., Siddique, T., O'Halloran, T.V. "Free in PMC Disulfide cross-linked protein represents a significant fraction of ALS-associated Cu, Zn-superoxide dismutase aggregates in spinal cords of model mice." Proc. Natl. Acad. Sci., 2006, 103, 7148-7153.
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  • Furukawa, Y., O'Halloran, T.V. "ALS Mutations have the Greatest Destabilizing Effect on the apo,reduced form of SOD1, Leading to unfolding and oxidative aggregation" J. Biol. Chem., 2005, 280, 17266-17274.
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  • Arnesano, F., Banci, L., Bertini, I., Martinelli, M., Furukawa, Y., O'Halloran, T.V. "The Unusually Stable Quaternary Structure of Human SOD1 is Controlled by Both Metal Occupancy and Disulfide Status" J. Biol. Chem. 2004, 279, 47998-48003.
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  • Culotta, V.C., O'Halloran, T.V. Metallochaperones, In Biological Inorganic Chemistry: Structure and Reactivity I. Bertini, H.B. Gray, E.I. Stiefel and J.S. Valentine, Eds. University Science Books, Mill Valley, CA, 2006

  • Furukawa, Y., Torres, A.S., O'Halloran, T.V. "Oxygen-induced MAturation of SOD1: A Key Role for Disulfide Formation by the Copper Chaperone CCS", The EMBO Journal, 2004, 23, 2872-2881.
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  • Brown, N.M., Torres, A.S., Doan, P.E., O'Halloran, T.V. "Oxygen and the Copper Chaperone CCS Regulate Post-Translational Activation of Cu,Zn Superoxide Dismutase" Proc. Natl. Acad. Sci., 2004, 101, 5518-5523.
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  • Taki, M., Wolford, J., O'Halloran, T.V. "Emission Ratiometric Imaging of Intracellular Zinc: Design of a Benzoxazole Fluorescent Sensor and its application in Two-Photon Microscopy" J. Amer. Chem. Soc., 2004, 126, 712-713.
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  • Chen, K., Yuldasheva, S., Penner-Hahn, J.E., O'Halloran, T.V. "An Atypical Linear Cu(I)-S2 Center Constitutes the High-Affinity Metal-Sensing Site in the CueR Metalloregulatory Protein" J. Amer. Chem. Soc., 2003, 125, 12088-12089.
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  • Changela, A., Chen, K., Xue, Y., Holschen, J., Outten, C.E., O'Halloran, T.V., Mondragon, A. "Molecular Basis of Selectivity and Zeptomolar Sensitivity by CueR" Science, 2003, 301, 1383-1387.
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  • Finney, L.A., O'Halloran, T.V. "Transition Metal Speciation in the Cell: Insights from the Chemistry of Metal Ion Receptors" Science, 2003, 300, 931-936.
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  • Peariso, K., Huffman, D.L., Penner-Hahn, J.E., and O'Halloran, T.V. "The PcoC Copper Resistance Protein Coordinates Cu(I) via Novel S-Methionine Interactions" J. Amer. Chem. Soc 2003, 125, 2, 342-343.
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  • Wernimont, A.K., Huffman, D.L., Finney, L.A., Demeler, B., O'Halloran, T.V., Rosenzweig, A.C. "Crystal structure and dimerization equilibria of PcoC, a methionine rich copper resistance protein from Escherichia coli" J. Biol. Inorg. Chem. 2003, 8, 185-194.
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  • Finney, L.A., Ciofi-Baffoni, S., Outten, C.E., Banci, L., Bertini, I., and O'Halloran, T.V. "A new zinc protein coordination site in an intracellular metal-trafficking protein: Solution structure of the apo and Zn(II) forms of ZntA(46-118)" J. Mol. Biol., 2002, 323, 883-897.
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  • Huffman, D.L., Huyett, J., Outten, F.W., Doan, P.E., Finney, L.A., Hoffman, B.M., O'Halloran, T.V., "ENDOR Spectroscopy of Cu(II)-PcoC and the Multicopper Oxidase Function of PcoA, Two Essential Components of the pco Copper Resistance Operon in Escherichia coli" Biochemistry, 2002, 41, 31, 10046-10055.
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  • Arnesano, F., Banci, L., Bertini, I., Ciofi-Baffoni, S., Molteni, E., Huffman, D.L., and O'Halloran, T.V. "Metallochaperones and Metal-Transporting ATPases: A Comparative Analysis of Sequences and Structures" Genome Research, 2002, 12, 255-271.
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  • Torres, A., Petri, V., Rae, T., O'Halloran, T. "Copper Stabilizes a Heterodimer of the yCCS Metallochaperone and its Target Superoxide Dismutase" J. Biol. Chem., 2001, 276, 38410-38416.
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  • Lamb, A.L., Torres, A.S., O'Halloran, T.V., Rosenzweig, A.C., "Heterodimeric structure of superoxide dismutase in complex with its metallochaperone" Nature Structural Biology 2001, 8, 751-755.
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  • Outten, C.E., O'Halloran, T.V., "Femtomolar Sensitivity of Metalloregulatory Proteins Controlling Zinc Homeostasis" Science 2001, 292, 2488-2492
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  • Hitomi, Y., Outten, C.E., O'Halloran, T.V "Extreme Zinc-binding Thermodynamics of the Metal Sensor/Regulator protein, ZntR" J. Amer. Chem. Soc. 2001, 123, 35, 8614-8615
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  • Outten, C.E., Tobin, D.A., Penner-Hahn, J.E., and O'Halloran, T.V. "Characterization of the Metal Receptor Sites in E. coli Zur, an Ultrasensitive Zn(II) Metalloregulatory Protein" Biochemistry 2001, 40, 35, 10417-10423.
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  • Outten, F.W., Huffman, D., Hale, J., O'Halloran, T.V., "The Independent cue and cus Systems Confer Copper Tolerance During Aerobic and Anaerobic Growth in Escherichia coli" J. Biol. Chem. 2001, 276, 30670-30677.
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  • Huffman, D., and O'Halloran, T. V. "Function, Structure, and Mechanism of Intracellular Copper-Trafficking Proteins" Ann. Rev. Biochemistry, 2001, 70, 677-701.
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  • Rae, T., Torres, A., Pufahl, R., O'Halloran, T. "Mechanism of Cu, Zn-Superoxide Dismutase Activation By the Human Metallochaperone CCS", J. Biol. Chem. 2001, 276, 7, 5166-5176.
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  • Arnesano, F., Banci, L., Bertini, I., Cantini, F., Ciofi-Baffoni, S., Huffman, D., O'Halloran, T.V., "Characterization of the Binding Interface between the Copper Chaperone Atx1 and the First Cytosolic Domain of Ccc2 ATPase" J. Biol. Chem. 2001, 276, 41365-41376.
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  • Banci, L., Bertini, I., Simone, C., Huffman, D., O'Halloran, T. "Solution Structure of the Yeast Copper Transporter Domain Ccc2a in the apo and Cu(I) Loaded States"J. Biol. Chem. 2001, 276, 8415-8426.
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  • Arnesano, F., Banci, L, Bertini, I., Huffman, D., and O'Halloran, T. "Solution structure of the Cu(I) and apo-forms of the Yeast Metallochaperone, Atx1" Biochemistry 2001, 40, 1528-1539.
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  • Lamb, A., Torres, A., O'Halloran, T. V., and Rosenzweig, A. C. "Heterodimer Formation between Superoxide Dismutase and Its Copper Chaperone" Biochemistry 2000, 39, 48, 14720-14727.
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  • Outten, F.W., Outten, C., Hale, J., and O'Halloran, T. "Transcriptional Activation of an E. coli Copper Efflux Regulon by the Chromosomal MerR Homologue, CueR" J. Biol. Chem.. 2000, 275, 31024-31029.
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  • Munson, G.P., Lam, D.L., Outten, F.W., and O'Halloran, T.V. "Identification of a Chromosomal Copper Responsive Regulatory Locus from Escherichia coli K12", J. Bacteriology 2000, 182, 5864-5871.
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  • Wernimont, A. K.; Huffman, D. L.; Lamb, A. L.; O'Halloran, T. V.; Rosenzweig, A. C. "Structural Basis for Metal Ion Transfer by the Copper Chaperone for the Menkes and Wilson Disease Protein" Nature Structural Biology 2000, 7, 9, 766-771.
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  • O'Halloran, T.V and Culotta V.C. "Metallochaperones: An Intracellular Shuttle Service for Metal Ions" J. Biol. Chem. 2000, 275, 33, 25057-25060.
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  • Huffman, D.L. and O'Halloran, T.V "Energetics of Copper Trafficking Between the Atx1 Metallochaperone and the Intracellular Copper-transporter, Ccc2" J. Biol. Chem.., 2000, 275, 25, 18611-18614.
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  • Rosenzweig, A.C. and O'Halloran, T.V., "Structure and Chemistry of the Copper Chaperone Proteins" Current Opinion in Chem. Biol., 2000, 4, 140-147.
  • Lamb, A.L., Wernimont, A.K., Pufahl, R.A., O'Halloran, T.V. and Rosenzweig, A.C. "Crystal Structure of the Second Domain of the Human Copper Chaperone for Superoxide Dismutase" Biochemistry, 2000, 39, 1589-1595.
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  • Outten, F.W., Outten, C.E. and O'Halloran, T.V. "Metalloregulatory Systems at the Interface Between Bacterial Metal Homeostasis and Resistance" In Bacterial Stress Responses, Storz, G., Ed. ASM Press 2000, 145-157.

  • Outten, C.E., Outten, F.W. and O'Halloran, T.V. "DNA Distortion Mechanism for Transcriptional Activation by ZntR, a Zn(II)-responsive MerR homologue in E. coli." J. Biol. Chem. 1999, 274, 37517-37524.
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  • Nasir, M.S., Fahrni, C.J., Suhy, D.A., Kolodsick, K.J., Singer, C.P. and O'Halloran, T.V. "The Chemical Cell Biology of Zinc: Structure and Intracellular Fluorescence of Zinc-Quinolinesulfonamide Complex" J. Biol. Inorg. Chem. 1999, 4, 775-783.
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  • Fahrni, C.J. and O'Halloran, T.V. "Aqueous Coordination Chemistry of Quinoline-based Fluorescence Probes for the Biological Chemistry of Zinc" J. Amer. Chem. Soc. 1999, 121, 49, 11448-11458.
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  • Fleissner, G., Kozlowski, P.M., Vargek, M., Bryson, J.W., O'Halloran, T.V. and Spiro, T.G. "UVRR Spectroscopy and Vibrational Analysis of Mercury Thiolate Compounds Resembling d10 Metal Binding Sites in Proteins" Inorg. Chem., 1999, 38, 3523-3528.
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  • Portnoy, M.E., Rosenzweig, A.C., Rae, T., Huffman, D.L., O'Halloran, T.V., and Culotta, V.C. "Sturcture-Function Analyses of the ATX1 Metallochaperone" J. Biol. Chem.. 1999, 274, 15041-15045.
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  • Schmidt, P.J., Rae, T.D., Pufahl, R.A., Strain, J., Hamma, T., O'Halloran, T.V., Culotta, V.C. "Multiple Protein Domains Contribute to the Action of the Copper Chaperone for Superoxide Dismutase" J. Biol. Chem.., >1999, 247, 23719-23725.
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  • Lamb, L.L., Wernimont, A.K., Pufahl, R.A., O'Halloran, T.V., Rosenzweig, A.C. "Crystal Structure of the Copper Chaperone for Superoxide Dismutase" Nature Structural Biology, 1999, 6, 724-729.
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    Note: See News and Views "Helping copper find a home" by T. Poulos, p. 709-711 in the same issue.

  • Rosenzweig, A.C., Huffman, D.L., Hou, M.Y., Wernimont, A.K., Pufahl, R.P., and O'Halloran, T.V. "Crystal Structure of the Atx1 Metallochaperone Protein at 1.02 A Resolution" Structure, 1999, 7, 605-617.
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  • Rae, T.D., Schmidt, P.J., Pufahl, R.A., Culotta, V.C., and O'Halloran, T.V. "Undetectable Free Intracellular Copper: the Requirement of a Copper Chaperone for Superoxide Dismutase" Science, 1999, 284, 805-808.

    Note: See Perspective "Free Copper Ions in the Cell" by S.J. Lippard, p. 748-749 in the same issue.

  • Althaus, E.W., Outten, C.E., Olson, K.E., Cao, H., and O'Halloran, T.V. "The Ferric Uptake Regulation (Fur) Repressor Is a Zinc Metalloprotein" Biochemistry, 1999, 38, 6559-6569.
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  • Suhy, D.A., Simon, K.D., Linzer, D.I.H., O'Halloran, T.V. "Metallothionein is Part of a Zinc-Scavenging Mechanism for Cell Survival Under Conditions of Extreme Zinc Deprivation" J. Biol. Chem., 1999, 274, 9183-9192.
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  • Pufahl, R.A. and O'Halloran, T.V. "Mechanisms of Copper Chaperone Proteins", In Metals and Genetics, B. Sarkar, Ed., New York, Plenum Publishing Corporation, 1999.

  • Valentine, J.S. and O'Halloran, T.V. "Bio-inorganic chemistry: what is it, and what's so exciting?" Current Opinion in Chemical Biology, 1999, 3, 129-130.
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  • Fleissner, G., Reigle, M.D., O'Halloran, T.V. and Spiro, T.G. "UVRR Spectroscopy of the Metal Receptor Site in MerR" J. Amer. Chem. Soc., 1998, 120, 12690-12691.
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  • Pufahl, R.A. and C.P. Singer, K.L. Peariso, S.-J. Lin, P. Schmidt, V. Cizewski Culotta, J.E. Penner-Hahn, T.V. O'Halloran, "Metal Ion Chaperone Function of the Soluble Cu(I) Receptor, Atx1" Science, 1997, 278, 853-856.
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    • See Perspective "Delivering Copper Inside Yeast and Human Cells" by J.S. Valentine and E.B. Gralla, pgs. 817-818 in the same issue.
  • Dieckmann, G.R., McRorie, D.K. Tierney, D.L., Utschig, L.M., Singer, C.P. O'Halloran, T.V. Penner-Hahn, J.E., DeGrado, W.F., Pecoraro, V.L. "The De Novo Design of Mercury-Binding Two- and Three-Helical Bundles." J. Amer. Chem. Soc., 1997, 119, 6195-6196.
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  • O'Halloran, T.V. and Malin, J.M. "Pentacyanoiron (III) Pyridine Derivatives as Topological Probes for Electron Transfer Cytochrome c," Kinetics and Catalysis, 1996, 37, 676-682.

  • Utschig, L., Baynard, T., Strong, C. and O'Halloran, T.V. . "Probing the Copper Coordination Chemistry of Rusticyanin and Azurin by 2D 1H-199Hg NMR" Inorg. Chem., 1997, 36, 2926-2927.
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  • Pufahl, R., Dancis, A., O'Halloran, T.V., Culotta, V.C. "A Role for the Saccharomyces cerevisiae ATX1 Gene in Copper Trafficking and Iron Transport" J. Biol. Chem., 1997, 272, 9215-9220.
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  • Huffman, D., Utschig, L and O'Halloran, T. V. " Mercury Responsive Gene Regulation and 199Hg as a Probe of Protein Structure." in Metal Ions in Biological Systems, H. Sigel, ed., Marcel Dekker, NY, Vol. 34, 1997, 503-526.
  • Kaplan, J. and O'Halloran, T.V. "Iron Metabolism in Eukaryotes: Mars and Venus at It Again", Science, 1996, 271, 1510-1512.

  • Suhy, D. and O'Halloran, T. "Metal Responsive Gene Regulation and the Zinc Metalloregulatory Model", in Metal Ions in Biological Systems, H. Sigel, ed., Marcel Dekker, NY, Vol. 32, 1995, 557-578.
  • Fackler, N., Zhang, S. and O'Halloran, T. "Stabilization of High Valent Terminal-oxo-complexes: The Interplay of D-orbital Occupancy and Coordination Geometry", J. Amer. Chem. Soc., 1996, 118, 481-482.
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  • Utschig, L., Wright, J., Dieckmann, G., Pecoraro, V. and O'Halloran, T. "The 199Hg Chemical Shift as a Probe of Coordination Environments in Blue Copper Proteins", Inorg. Chem., 1995, 34, 2497-2498.
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  • Utschig, L., Bryson, J., O'Halloran, T. "Mercury-199 NMR of the Metal Receptor Site in MerR and Its Protein-DNA Complex", Science, 1995, 268, 380-385.
  • Ansari, A.Z., Bradner, J.E., O'Halloran, T.V. "DNA Bend Modulation in a Repressor -to-Activator Switching Mechanism". Nature, 1995, 374, 371-375.
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  • Han, M.; Peersen, O.B.; Bryson, J.W.; O'Halloran, T.V.; Smith, S.O. "Enhanced Cross Polarization in Magic Angle Spinning NMR of Metal Complexes", Inorg. Chem., 1995, 34, 1187-1192.
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  • MacDonnell, F.; Fackler, T.; Stern, C.; O'Halloran, T.V. "Air Oxidation of Five Coordinate, Alkoxide Bridged Mn(III) Dimer to Mn(V) Oxo Complex". J. Amer. Chem. Soc., 1994, 116, 7431-7432.
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  • Ansari, A. Z., O'Halloran, T.V., "An Emerging Role for Allosteric Modulation of DNA Structure in Transcription" in Mechanisms and Regulation, R.C. Conaway, J.W. Conaway, eds., Raven Press, New York, 1994. p. 369-386.
  • Broderick, J.; Natan, M.J.; Van Duyne, R.P.; O'Halloran, T.V. "Evidence for Retention of Biological Activity of a Non-Heme Iron Enzyme Adsorbed on a Silver Colloid: A Surface-Enhanced Resonace Raman Scattering Study". Biochemistry, 1993, 32, 13771-13776.
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  • O'Halloran, T. V. "Transition Metals in Control of Gene Expression". Science, 1993, 261, 715-725.
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  • Utschig, L.; Wright, J.; O'Halloran, T.V. "Preparation and Spectroscopic Characterization of Mercury Complexes of Metalloproteins". Methods in Enzymology: Metallobiochemistry: Part C, Vol. 226, Editors: J.F. Riordan, B.L. Vallee, New York: Academic Press, 1993 p. 71-97

  • Bryson, J.W.; O'Halloran, T.V.; Rouch, D.A.; Brown, N.L.; Camakaris, J.; Lee, B.T.O.; "Chemical and Genetic Studies of Copper Resistance in E. coli". Bioinorganic Chemistry of Copper, K. D. Karlin and Z. Tyeklar, eds., Chapman & Hall, NewYork, 1993, p. 101-109.

  • Parkhill, J.; Ansari, A.Z.; Wright, J.G.; Brown, N.L.; O'Halloran, T.V.; "Construction and Characterization of a Mercury-Independent MerR Activator (MerRAC): Transcriptional Activation in the Absence of Hg(II) is Accompanied by DNA Distortion", European Molecular Biology Organization (EMBO) Journal, 1993, 12, 413-421.
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  • Clark, K.; Utschig, L.; O'Halloran, T.V.; Penner-Hahn, J.E. "Structural Characterization of the Binding Site in the MerR Metalloregulatory Protein", Jpn. J. Appl. Phys., 1993, 32, 536-537.
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    • Ansari, A.Z., Chael, M.L., O'Halloran, T.V. "Allosteric Underwinding of DNA is a Critical Step in Positive Control of Transcription by MerR", Nature, 1992, 355, 87-89.
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  • Kirtley, S.M., Mullins, O.C., Chen, J., Elp, J.V., George, S.J., Chen, C.T., O'Halloran, T.V., Cramer, S.P. "Nitrogen Chemical Structure in DNA and Related Molecules by X-ray Absorption Spectroscopy", Biochim. Biophys. Acta, 1992, 1132, 3, 249-254.
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  • Broderick, J.B., O'Halloran, T.V., "Overproduction, Purification, and Characterization of a Chlorocatechol Dioxygenase, a Non-Heme Iron Dioxygenase with Broad Substrate Tolerance", Biochemistry, 1991, 30, 7349-7358.

  • Frantz, B., O'Halloran, T.V., "DNA Distortion Accompanies Transcriptional Activation by a Metal-Responsive Gene-Regulatory Protein MerR", Biochemistry, 1990, 29, 4747-4751.

  • Ralston, D.M. and O'Halloran, T.V. "Ultrasensitivity and heavy-metal selectivity of the allosterically modulated MerR transciption complex", Proceedings of the National Academy of Science, 1990, 87, 3846-3850.

  • Ralston, D.M., O'Halloran, T.V., "Metalloregulatory Proteins and Molecular Mechanisms of Heavy Metal Signal Transduction", in Advances in Inorganic Biochemistry, G. Eichhorn, L. Marzilli eds. Elsevier, New York 1990, 1-32.

  • Watton, S.P., Wright, J.G., MacDonnell, F.M., Bryson, J.W., Sabat, M., O'Halloran, T.V., "Trigonal Mercuric Complex of an Aliphatic Thiolate: A Spectroscopic and Structural Model for the Receptor Site in the Hg(II) Biosensor MerR", J. Amer. Chem. Soc., 1990, 112, 2824-2826.

  • Natan, M.J., Millikan, C.F., Wright, J.G., O'Halloran, T.V., "Solid-State 199Hg Nuclear Magnetic Resonance as a Probe of Coordination Number and Geometry in Hg(II) Complexes", J. Amer. Chem. Soc., 1990, 112, 3255-3257.

  • Wright, J.G., Tsang, H-T, Penner-Hahn, J.E., O'Halloran, T.V., "Coordination Chemistry of the Hg-MerR Metalloregulatory Protein: Evidence for a Novel Tridentate Hg-Cysteine Receptor Site", J. Amer. Chem. Soc., 1990, 112, 2434-2435.

  • Wright, J.W., Natan, M.J., MacDonnell, F.M., Ralston, D.M., O'Halloran, T.V., "Mercury(II) Thiolate Chemistry and the Mechanism of the Heavy Metal Biosensor MerR", in Progress in Inorganic Chemistry, S.J. Lippard, ed. John Wiley & Sons, New York, 1990, 38, 323-412.

  • Frantz, B.; O'Halloran, T.V., "Inorganic Reagents as Probes for the Mechanism of a Metal-Responsive Genetic Switch", in Transition-Metal Nucleic Acid Chemistry, T. Tullius, ed. ACS Books: Washington, DC, 1989, pp. 97-105.

  • O'Halloran, T.V.; Frantz, B.; Shin, M.K.; Ralston, D.M.; Wright, J.G., "The MerR Heavy Metal Receptor Mediates Positive Activation in a Topologically Novel Transcription Complex" Cell, 1989, 56, 119-129.

  • O'Halloran, T.V., "Metalloregulatory Proteins: Metal Responsive Molecular Switches Governing Gene Expression", in Metal Ions in Biological Systems, H. Sigel, ed., Marcel Dekker, NY, Vol. 25, 1989 pp. 105-146.

  • Ralston, D.; Frantz, B.; Shin, J.; Wright, J.; O'Halloran, T.V., "In Vitro Analysis of the MerR Metalloregulatroy Protein: A Heavy Metal-Responsive Regulator of Gene Expression", in Metal Ion Homeostasis: Molecular Biology and Chemistry; UCLA Symposium on Molecular and Cellular Biology , New Series Vol. 98, D. Winge and D. Hamer eds., Alan Liss, Inc. New York, New York, 1989, 407-416.

  • O'Halloran, T.V.; Lippard, S.J., "Isomerization of Binuclear Amidate- Bridged Platinum(II) Amine Complexes -- A 195Pt NMR Investigation", Inorg. Chem., 1989, 27, 1289-1295.

  • O'Halloran, T.V.; Walsh, C.T., "Metalloregulatory DNA-Binding Protein Encoded by MerR Gene: Isolation and Characterization." Science, 1987, 235, 211-214.

  • O'Halloran, T.V.; Lippard, S.J.; Richmond, T.J.; Klug, A., "Multi Heavy-atom Reagents for Macromolecular X-ray Structure Determination: Application to the Nucleosome Core Particle." J. Mol. Biol., 1987, 194, 705-712.

  • O'Halloran, T.V.; Mascharak, P.K.; Williams, I.D.; Roberts, M.M.; Lippard, S.J., "Synthesis, Structure Determination, and Electronic Structure Characterization of Two Mixed-Valence Tetranuclear Platinum Blues with Bridging a-Pyridonate or 1-Methyluracilate Ligands." Inorg. Chem., 1987, 26, 1261-1270.

  • O'Halloran, T.V.; Roberts, M.M.; Lippard, S.J., "Synthesis, Structure, and 195Pt NMR Solution Studies of a Reactive Binuclear Platinum(III) Complex: [Pt2(en)2(C5H4NO)2(NO2)(NO3)](NO3)2.0.5 H2O." Inorg. Chem., 1986, 25, 957-964.

  • O'Halloran, T.V.; "Structural, Theoretical, and 195Pt NMR Solution Studies of the Platinum Blues and Related Clusters Containing Platinum in the +2 and +3 Oxidation States." Doctoral Thesis, Columbia University, New York, 1985, 1-273.

  • O'Halloran, T.V.; Lippard, S.J., "The Chemistry of Platinum in the +3 Oxidation State." Isrl. J. Chem., 1985, 25, 130-137.

  • O'Halloran, T.V.; Roberts, M.M.; Lippard, S.J., "Correlation between Metal-Metal Distances and Optical Spectrosco py in the Platinum Blues: Synthesis, Crystal Structure, and Electronic Spectrum of Ethylenediamineplatinum a-Pyridone Blue." J. Amer. Chem. Soc., 1984, 106, 6427-6428.

  • Ginsberg, A.P.; O'Halloran, T.V.; Fanwick, P.E.; Hollis, L.S.; Lippard, S.J., "Electronic Structure and Optical Spectrum of cis-Diammineplatinum a-Pyridone Blue: Metal-Metal Bonding and Charge Transfer in a Four-Atom Pt(2.25) Chain", J. Amer. Chem. Soc., 1984, 106, 5430-5439.

  • O'Halloran, T.V.; Lippard, S.J., "195Pt NMR Investigation of the Head-to-Head to Head-to-Tail Isomerization of a-Pyridonate-Bridged Ethylenediamine Platinum(II) Dimer", J. Amer. Chem. Soc., 1983, 105, 3341-3342.

  • O'Halloran, T.V., "Pentacyanoiron(III) Pyridine Derivatives: Topological Probes for Electron Transfer Proteins." Masters Thesis, University of Missouri, Columbia, 1980, 1-75.

  • Malin, J.M.; Ryan, D.P.; O'Halloran, T.V., "Thermal and Light-Induced Electron Transfer between Iron(II) and Cobalt(III) Mediated by Bridging Pyrazines." J. Amer. Chem. Soc., 1978, 100, 2097-2102.

  • O'Halloran, T.V.; Malin, J.M., "Cis-bis-(Dimethylsulfoxide)tetraammine-cobalt(III) and related complex ions [1]." J. Nucl. Inor. Chem., 1978, 41, 117-119.