|
Synthesis Subgroup |
|
The Synthesis subgroup aims to synthesize and characterize novel porphyrin-derivatives (porphyrazines, or pzs) for a variety of biomedical and material applications |
|
Materials Applications |
|
Porphyrazine Nanoinks |
|
Development of pz “nanoinks” that form surface structures with electrical conductivities that can be controllably varied. |
|
Sulfide appended porphyrazine 1 with lateral force microscope pictures shown. |
|
Collaboration with Mirkin Group |
|
Collaboration with Meade group, Sloan group (Wayne St.) and Radosevich group (UIC). |
|
The Hoffman Group |
|
Synthesis of novel fluorescent dyes based on porphyrazines with electronic absorption in the window of maximum tissue penetration (~ 700-900nm) for the detection and treatment of superficial cancers. |
|
Funding: Penny Severns Breast, Cervical, and Ovarian Cancer Research Fund
|
|
Biomedical Applications |
|
Porphyrazine Imaging/Therapeutic Agents |
|
Mouse with subcutaneous tumors stably expressing red fluorescent protein (RFP). X-ray/optical overlay of (A) RFP emission, (B) false green porphyrazine 247 emission, and (C) merged image indicating co-localization. |
