Recent Publications (2010-current)

The Hoffman Group

 

Photoinduced Reductive Elimination of H2 from the Nitrogenase Dihydride (Janus) State Involves a FeMo-cofactor-H2 Intermediate, Lukoyanov, D.; Khadka, N.; Dean, D.R.; Raugei, S.; Seefeldt, L.C.; Hoffman, B.M, Inorganic Chemistry, 2017, 56, 2233-2240.

 

13C ENDOR Spectroscopy of Lipoxygenase-Substrate Complexes Reveals the Structural Basis for C-H Activation by Tunneling, Horitani, M.; Offenbacher, A.R.; Carr, C.A.M.; Yu, T.; Hoeke, V.; Cutsail III, G.E.; Hammes-Schiffer, S.; Klinman, J.P.; Hoffman, B.M., Journal of the American Chemical Society, 2017, 139, 1984-1997.

 

Metal Selectivity of a Cd-, Co-, and Zn-Transporting P1B-type ATPase, Smith, A.T.; Ross, M.O.; Hoffman, B.M.; Rosenzweig, A.C., Biochemistry, 2017, 56, 85-95.

 

Negative Cooperativity in the Nitrogenase Fe Protein Electron Delivery Cycle, Danyal, K.; Shaw, S.; Page, T.R.; Duval, S.; Fielding, A.J.; Horitani, M.; Marts, A.R.; Lukoyanov, D.; Dean, D.R.; Raugei, S.; Hoffman, B.M.; Seefeldt, L.C.; Antony, E., Proceedings of the National Academy of Science, 2016, 113, E5783-E5791.

 

Charge-Disproportionation Symmetry Breaking Creates a Heterodimeric Myoglobin Complex with Enhanced Affinity and Rapid Intracomplex Electron Transfer, Trana, E.N.; Nocek, J.M.; Vander Woude, J.; Span, I.;Smith, S.M.; Rosenzweig, A.; Hoffman, B.M., Journal of the American Chemical Society, 2016, 138, 12615-12628.

 

Characterization of Methanobactin from Methylosinus sp. LW4, Kenney, G.E.; Goering, A.W.; Ross, M.O.; DeHart, C.J.; Thomas, P.M.; Hoffman, B.M.; Kelleher, N.L.; Rosenzweig, A.C., Journal of the American Chemical Society, 2016, 138, 11124-11127.

 

Reductive Elimination of H2 Activates Nitrogenase to Reduce the N≡N Triple Bond: Characterization of the E4(4H) Janus Intermediate in Wild-Type Enzyme, Lukoyanov, D.; Khadka, N.; Yang, Z.-Y.; Dean, D.R.; Seefeldt, L.C.; Hoffman, B.M., Journal of the American Chemical Society, 2016, 138, 10674-10683.

 

Organometallic Complex Formed by an Unconventional Radical SAM Enzyme, Dong, M.; Horitani, M.; Dzikovski, B.; Pandelia, M.-E.; Krebs, C.; Freed, J.; Hoffman, B.; Lin, H., Journal of the American Chemical Society, 2016, 138, 9755-9758.

 

CO2 Reduction Catalyzed by Nitrogenase: Pathways to Formate, Carbon Monoxide, and Methane, Khadka, N.; Dean, D.R.; Smith, D.; Hoffman, B.M.; Raugei, S.; Seefeldt, L, Inorganic Chemistry, 2016, 55, 8321-8330.

 

Exploring Electron/Proton Transfer and Conformational Changes in the Nitrogenase MoFe Protein and FeMo-cofactor Through Cryoreduction/EPR Measurements, Davydov, R.; Khadka, N.; Yang, Z.-Y.; Fielding, A.J.; Lukoyanov, D.; Dean, D.R.; Seefeldt, L.C.; Hoffman, B.M., Israel Journal of Chemistry, 2016, 56, 841-851.

 

Ultrafast Excited State Relaxation of a Metalloporphyrin Revealed by Femtosecond X‑ray Absorption Spectroscopy, Shelby, M.L.; Lestrange, P.J.; Jackson, N.E.; Haldrup, K.; Mara, M.W.; Stickrath, A.B.; Zhu, D.; Lemke, H.T.; Chollet, M.; Hoffman, B.M.; Li, X.; Chen, L.X., Journal of the American Chemical Society, 2016, 138, 8752-8764.

 

Radical SAM Catalysis Via an Organometallic Intermediate with an Fe-[5'-C]-Deoxyadenosyl Bond, Horitani, M,; Shisler, K.; Broderick, W.E.; Hutcheson, R.U.; Duschene, K.S.; Marts, A.R.; Hoffman, B.M.; Broderick, J.B., Science, 2016, 352, 822-825.

 

Reversible Photoinduced Reductive Elimination of H2 from the Nitrogenase Dihydride State, the E4(4H) Janus Intermediate, Lukoyanov, D.; Khadka, N.; Yang, Z.-Y.; Dean, D.R.; Seefeldt, L.C.; Hoffman, B.M., Journal of the American Chemical Society, 2016, 138, 1320-1327.

 

Role of the Proximal Cysteine Hydrogen Bonding Interaction in Cytochrome P450 2B4 Studied by Cryoreduction, Electron Paramagnetic Resonance, and Electron-Nuclear Double Resonance Spectroscopy,

Davydov, R.; Im, S.; Shanmugam, M.; Gunderson, W.A.; Pearl, N.M.; Hoffman, B.M.; Waskell, L., Biochemistry, 2016, 55, 869-883.

 

Spectroscopic and Crystallographic Evidence for the Role of a Water-Containing H-Bond Network in Oxidase Activity of an Engineered Myoglobin, Petrik, I.D.; Davydov, R.; Ross, M.; Zhao, X.; Hoffman, B.; Lu, Y., Journal of the American Chemical Society, 2016, 138, 1134-1137.

 

Comparison of the Mechanisms of Heme Hydroxylation by Heme Oxygenases-1 and -2: Kinetic and Cryoreduction Studies, Davydov, R.; Fleischhacker, A.S.; Bagai, I.; Hoffman, B.M.; Ragsdale, S.W., Biochemistry, 2016, 55, 62-68.

 

Composition and Structure of the Inorganic Core of Relaxed Intermediate X(Y122F) of Escherichia Coli Ribonucleotide Reductase, Doan, P.E.; Shanmugam, M.; Stubbe, J.; Hoffman, B.M., Journal of the American Chemical Society, 2015, 137, 15558-15566.

 

Evidence that Compound I is the Active Species in Both the Hydroxylase and Lyase Steps by Which P450scc Converts Cholesterol to Pregnenolone: EPR/ENDOR/Cryoreduction/Annealing Studies, Davydov, R.; Strushkevich, N.; Smil, D.; Yantsevich, A.; Gilep, A.; Usanov, S.; Hoffman, B.M., Biochemistry, 2015, 54, 7089-7097.

 

Characterization of an Fe≡N-NH2 Intermediate Relevant to Catalytic N2 Reduction to NH3, Anderson, J. S.; Cutsail III, G. E.; Rittle, J.; Connor, B. A.; Gunderson, W. A.; Zhang, L.; Hoffman, B. M.; Peters, J. C., Journal of the American Chemical Society, 2015, 137, 7803-7809.

 

Why Nature Uses Radical SAM Enzymes so Widely: Electron Nuclear Double Resonance Studies of Lysine 2,3-Aminomutase Show the 5’-dAdo•‘Free Radical’ is Never Free, Horitani, M.; Byer, A. S.; Shisler, K. A.; Chandra, T.; Broderick, J. B.; Hoffman, B. M. Journal of the American Chemical Society, 2015, 137, 7111-7121.

 

The C-Terminal Heme Regulatory Motifs of Heme Oxygenase-2 Are Redox-Regulated Heme Binding Sites, Fleischhacker, B. M.; Sharma, A.; Choi, M.; Spencer, A. M.; Bagai I.; Hoffman, B. M.; Ragsdale, S. W. Biochemistry, 2015, 54, 2709-2718.

 

Spectroscopic Studies Reveal That the Heme Regulatory Motifs of Heme Oxygenase‑2 Are Dynamically Disordered and Exhibit Redox-Dependent Interaction with Heme, Bagai, I.; Sarangi, R.; Fleischhacker, A. S.; Sharma, A.; Hoffman, B. M.; Zuiderweg, E. R. P.; Ragsdale, S. W. Biochemistry, 2015, 54, 2693-2708.

 

Identification of a Key Catalytic Intermediate Demonstrates That Nitrogenase Is Activated by the Reversible Exchange of N2 for H2, Lukoyanov, D.; Yang, Z.-Y.; Khadka, N.; Dean, D. R.; Seefeldt, L. C.; Hoffman, B. M. Journal of the American Chemical Society, 2015, 137, 3610-3615.

 

Advanced Paramagnetic Resonance Spectroscopies of Iron-Sulfur Proteins:  Electron Nuclear Double Resonance (ENDOR) and Electron Spin Echo Envelope Modulation (ESEEM), Cutsail III, G. E.; Telser, J.; Hoffman, B. M. BBA - Molecular Cell Research, 2015, 1853, 1370-1394.

 

Control of Cyclic Photoinitiated Electron Transfer between Cytochrome c Peroxidase (W191F) and

Cytochrome c by Formation of Dynamic Binary and Ternary Complexes, Page, T. R.; Hoffman, B. M. Biochemistry, 2015, 54, 1188-1197.

 

Nitrite and Hydroxylamine as Nitrogenase Substrates: Mechanistic Implications for the Pathway of N2 Reduction, Shaw, S.; Lukoyanov, D.; Danyal, K.; Dean, D. R.; Hoffman, B. M.; Seefeldt, L. C. Journal of the American Chemical Society 2014, 136, 12776-12783.

 

Generating and Stabilizing Co(I) in a Nanocage Environment, Shen, J.; Kung, M. C.; Shen, Z.; Wang, Z.; Gunderson, W. A.; Hoffman, B. M.; Kung, H.H. Journal of the American Chemical Society 2014, 136, 5185-5188.

 

Internal Dynamics of a Supramolecular Nanofibre, Ortony, J. H.; Newcomb, C. J.; Matson, J. B.; Palmer, L. C.; Doan, P. E.; Hoffman, B. M.; Stupp, S. I. Nature Materials 2014, 13, 812-816.

 

Free H2 Rotation vs Jahn-Teller Constraints in the Nonclassical Trigonal (TPB)Co-H2 Complex, Gunderson, W. A.; Suess, D. L. M.; Fong, H.; Wang, X.; Hoffmann, C. M.; Cutsail III, G. E.; Peters, J. C.; Hoffman, B. M. Journal of the American Chemical Society 2014, 136, 14998-15009.

 

Symmetrized Photoinitiated Electron Flow within the [Myoglobin:Cytochrome b5 Complex on Singlet and Triplet Time Scales: Energetics vs Dynamics, Co, N. P.; Young, R. M.; Smeigh, A. L.; Wasielewski, M. R.; Hoffman, B. M. Journal of the American Chemical Society 2014, 136, 12730-12736.

 

Enzymatic and Cryoreduction EPR Studies of the Hydroxylation of Methylated Nw-Hydroxy-L-arginine Analogues by Nitric Oxide Synthase from Geobacillus stearothermophilus, Davydov, R.; Labby, K. J.; Chobot, S. E.; Lukoyanov, D. A.; Crane, B. R.; Silverman, R. B.; Hoffman, B. M. Biochemistry 2014, 53, 6511-6519.

 

Identification of the Valence and Coordination Environment of the Particulate Methane Monooxygenase Copper Centers by Advanced EPR Characterization, Culpepper, M. A.; Cutsail III, G. E.; Gunderson, W. A.; Hoffman, B. M.; Rosenzweig, A. C. Journal of the American Chemical Society 2014, 136, 11767-11775.

 

EPR, ENDOR, and Electronic Structure Studies of the Jahn-Teller Distortion in an FeV Nitride, Cutsail III, G. E.; Stein, B. W.; Subedi, D.; Smith, J. M.; Kirk, M. L.; Hoffman, B. M. Journal of the American Chemical Society 2014, 136, 12323-12336.

 

Electron Paramagnetic Resonance and Electron-Nuclear Double Resonance Studies of the Reactions of Cryogenerated Hydroperoxoferric-Hemoprotein Intermediates, Davydov, R.; Laryukhin, M.; Ledbetter-Rogers, A.; Sono, M.; Dawson, J. H.; Hoffman, B.M. Biochemistry 2014, 53, 4894-4903.

 

A Confirmation of the Quench-Cryoannealing Relaxation Protocol for Identifying Reduction States of Freeze-Trapped Nitrogenase Intermediates, Lukoyanov, D.; Yang, Z.-Y.; Duval, S.; Danyal, K.; Dean, D. R.; Seefeldt, L. C.; Hoffman, B. M. Inorganic Chemistry 2014, 53, 3688-3693.

 

Synthesis and Characterization of a Porphyrazine-Gd(III) MRI Contrast Agent and in vivo Imaging of a Breast Cancer Xenograft Model, Trivedi, E. R.; Ma, Z.; Waters, E. A.; Macrenaris, K. W.; Subramanian, R.; Barrett, A. G. M.; Meade, T. J.; Hoffman, B. M. Contrast Media & Molecular Imaging 2014, 9, 313-322.

 

Mechanism of Nitrogen Fixation by Nitrogenase: The Next Stage, Hoffman, B. M.; Lukoyanov, D.; Yang, Z.-Y.; Dean, D. R.; Seefeldt, L. C. Chemical Reviews 2014, 114, 4041-4062.

 

Generation of High-Spin Iron(I) in a Protein Environment Using Cryoreduction, Davydov, R. M.; McLaughlin, M. P.; Bill, E.; Hoffman, B. M.; Holland, P. L. Inorganic Chemistry 2013, 52, 7323-7325.

 

Electron Transfer Precedes ATP Hydrolysis During Nitrogenase Catalysis, Duval, S.; Danyal, K.; Shaw, S.; Lytle, A. K.; Dean, D. R.; Hoffman, B. M.; Antony, E.; Seefeldt, L. C. PNAS 2013, 110, 16414-16419.

 

On Reversible H2 Loss upon N2 Binding to FeMo-Cofactor of Nitrogenase, Yang, Z.-Y.; Khadka, N.; Lukoyanov, D.; Hoffman, B. M.; Dean, D. R.; Seefeldt, L. C. PNAS 2013, 110, 16327-16332.

 

The Use of Deuterated Camphor as a Substrate in 1H ENDOR Studies of Hydroxylation by Cryoreduced Oxy P450cam Provides New Evidence of the Involvement of Compound I, Davydov, R.; Dawson, J. H.; Perera, R.; Hoffman, B. M. Biochemistry 2013, 52, 667-671.

 

Distance-Independent Charge Recombination Kinetics in Cytochrome c-Cytochrome c Peroxidase Complexes: Compensating Changes in the Electronic Coupling and Reorganization Energies, Jiang, N.; Kuznetsov, A.; Nocek, J. M.; Hoffman, B. M.; Crane, B. R.; Hu, X.; Beratan, D. N. J Phys Chem B 2013, 117, 9129-41.

 

Responses of Mn2+ speciation in Deinococcus radiodurans and Escherichia coli to γ-radiation by advanced paramagnetic resonance methods, Sharma, A.; Gaidamakova, E. K.; Matrosova, V. Y.; Bennett, B.; Daly, M. J.; Hoffman Brian, M.  PNAS 2013, 110, 5945-5950.

 

Nitrogenase: A Draft Mechanism, Hoffman, B. M.; Lukoyanov, D.; Dean Dennis, R.; Seefeldt Lance, C.  Accounts of Chemical Research 2013, 46, 587-595.

 

Electronic spectra of porphyrins in the solid state: Newly observed transitions, collective and structural effects, and protein-mimicking environments, Musselman, R.L., Larsen, R.W., Hoffman, B.M. Coordination Chemistry Reviews 2012, 2, 369-380.

 

(1)H-ENDOR Evidence for a Hydrogen-Bonding Interaction That Modulates the Reactivity of a Nonheme Fe(IV)=O Unit, Shanmugam, M.; Xue, G.; Que, L., Jr.; Hoffman, B. M.  Inorg Chem 2012, 51, 10080-2.

 

A Closer Look at the Spectroscopic Properties of Possible Reaction Intermediates in Wild-Type and Mutant(E)-4-Hydroxy-3-methylbut-2-enyl Diphosphate Reductase. Biochemistry, Xu, W., Lees, N.S., Hall, D., Welideniya, D., Hoffman, B.M., Duin, E.C. Biochemistry 2012, 51, 4835-4849.

 

Characterization of a Cobalt-Specific P1B-ATPase, Zielazinski, E. L.; Cutsail, G. E.; Hoffman, B. M.; Stemmler, T. L.; Rosenzweig, A. C.  Biochemistry 2012, 51, 7891-7900.

 

Characterization of the Fe-H Bond in a Three-Coordinate Terminal Hydride Complex of Iron(I), Chiang, K.; Scarborough, C.; Horitani, M.; Lees, N.; Ding, K.; Dugan, T.; Brennessel, W.; Bill, E.; Hoffman, B.; Holland, P.  Angewandte Chemie International Edition 2012, 51, 1-6.

 

Compound I Is the Reactive Intermediate in the First Monooxygenation Step during Conversion of Cholesterol to Pregnenolone by Cytochrome P450scc: EPR/ENDOR/Cryoreduction/Annealing Studies, Davydov, R.; Gilep, A. A.; Strushkevich, N. V.; Usanov, S. A.; Hoffman, B. M.  Journal of the American Chemical Society 2012, 134, 17149-17156.

 

Electron transfer in nitrogenase catalysis, Seefeldt, L. C.; Hoffman, B. M.; Dean, D. R.  Current Opinion in Chemical Biology 2012, 16, 19-25.

 

EPR and 57Fe ENDOR investigation of 2Fe ferredoxins from Aquifex aeolicus, Cutsail, G. E., III; Doan, P. E.; Hoffman, B. M.; Meyer, J.; Telser, J.  Journal of Biological Inorganic Chemistry 2012, 17, 1137-1150.

 

Evidence for Oxygen Binding at the Active Site of Particulate Methane Monooxygenase, Culpepper, M.; Cutsail, G.; Hoffman, B.; Rosenzweig, A.  Journal of the American Chemical Society 2012, 134, 7640-7643.

 

Evolving the [Myoglobin, Cytochrome b(5)] Complex from Dynamic toward Simple Docking: Charging the Electron Transfer Reactive Patch, Trana, E. N.; Nocek, J. M.; Knutson, A. K.; Hoffman, B. M.  Biochemistry 2012, 51, 8542-8553.

 

Interfacial Hydration, Dynamics and Electron Transfer: Multi- Scale ET Modeling of the Transient [Myoglobin, Cytochrome b5] Complex, Keinan, S.; Nocek, J. M.; M., H. B.; Beratan, D. N.  Physical Chemistry Chemical Physics 2012, 14, 13881-13889.

 

Modeling the Signatures of Hydrides in Metalloenzymes: ENDOR analysis of a di-iron Fe(μ-NH)(μ-H)Fe core, Kinney, R. A.; Saouma, C. T.; Peters, J. C.; Hoffman, B. M.  Journal of the American Chemical Society 2012, 134, 12637-47.

 

Multi-gram synthesis of a porphyrazine platform for cellular translocation, conjugation to Doxorubicin and cellular uptake, Trivedi, E. R.; Blumenfeld, C. M.; Wielgos, T.; Pokropinski, S.; Dande, P.; Hai, T.; Barrett, A. G. M.; Hoffman, B. M.  Tetrahedron Letters 2012, 53, 5475-5478.

 

Temperature Invariance of the Nitrogenase Electron Transfer Mechanism, Mayweather, D.; Danyal, K.; Dean, D. R.; Seefeldt, L. C.; Hoffman, B. M.  Biochemistry 2012, 51, 8391-8.

 

Unification of Reaction Pathway and Kinetic Scheme for N2 Reduction Catalyzed by Nitrogenase, Lukoyanov, D.; Yang, Z.-Y.; Barney, B. M.; Dean, D. R.; Seefeldt, L. C.; Hoffman, B. M.  Proceedings of the National Academy of Sciences of the United States of America 2012, 109, 5583-5587.

 

Use of deuterated camphor as substrate in 1H ENDOR studies of hydroxylation by cryoreduced oxy P450cam provides new evidence for the involvement of compound I, Davydov, R.; Dawson, J.; Perera, R.; Hoffman, B.  Biochemistry 2012, 52, 667-671.

 

57Fe ENDOR Spectroscopy and ‘Electron Inventory’ Analysis of the Nitrogenase E4 Intermediate Suggest the Metal-Ion Core of FeMo-cofactor Cycles Through Only One Redox Couple, Doan, P. E.; Telser, J.; Barney, B. M.; Igarashi, R. Y.; Dean, D. R.; Seefeldt, L. C.; Hoffman, B. M.  Journal of the American Chemical Society 2011, 133, 17329–17340.

 

A Nonclassical Dihydrogen Adduct of S = 1/2 Fe(I), Lee, Y.; Kinney, R. A.; Hoffman, B. M.; Peters, J. C.  Journal of the American Chemical Society 2011, 133, 16366-16369.

 

Active intermediates in heme monooxygenase reactions as revealed by cryoreduction/annealing, EPR/ENDOR studies, Davydov, R.; Hoffman, B. M.  Archives of Biochemistry and Biophysics 2011, 507, 36-43.

 

Crystal structure and characterization of particulate methane monooxygenase from Methylocystis species strain M, Smith, S.; Rawat, S.; Telser, J.; Hoffman, B.; Stemmler, T.; Rosenzweig, A.  Biochemistry 2011, 50, 10231–10240.

 

ENDOR/HYSCORE studies of the common intermediate trapped during nitrogenase reduction of N2H2, CH3N2H, and N2H4 support an alternating reaction pathway for N2 reduction, Lukoyanov, D.; Dikanov, S. A.; Yang, Z.-Y.; Barney, B. M.; Samoilova, R. I.; Narasimhulu, K. V.; Dean, D. R.; Seefeldt, L. C.; Hoffman, B. M.  Journal of the American Chemical Society 2011, 133, 11655-11664.

 

Transformation of an [Fe(η2-N2H3)]+ Species to π-Delocalized [Fe2(μ-N2H2)]2+/+ Complexes, Saouma, C. T.; Kinney, R. A.; Hoffman, B. M.; Peters, J. C.  Angewandte Chemie, International Edition 2011, 50, 3446-3449, S3446/1-S3446/36.

 

Combining steady-state and dynamic methods for determining absolute signs of hyperfine interactions: Pulsed ENDOR Saturation and Recovery (PESTRE), Doan, P. E.  Journal of Magnetic Resonance 2011, 208, 76-86.

Design, Implementation, Simulation, and Visualization of a Highly Efficient RIM Microfluidic Mixer for Rapid Freeze-Quench of Biological Samples, Schmidt, B.; Mahmud, G.; Soh, S.; Kim, S. H.; Page, T.; O'Halloran, T. V.; Grzybowski, B. A.; Hoffman, B. M.  Applied Magnetic Resonance 2011, (11 February 2011), 1-11.

 

Temperature-dependent spin crossover in neuronal nitric oxide synthase bound with the heme-coordinating thioether inhibitors, Doukov, T.; Li, H.; Sharma, A.; Martell, J. D.; Soltis, S. M.; Silverman, R. B.; Poulos, T. L.  Journal of the American Chemical Society 2011, 133, 8326-8334.

 

Syntheses, Electronic Structures, and EPR/UV-Vis-NIR Spectroelectrochemistry of Nickel(II), Copper(II), and Zinc(II) Complexes with a Tetradentate Ligand Based on S-Methylisothiosemicarbazide, Arion, V. B.; Rapta, P.; Telser, J.; Shova, S. S.; Breza, M.; Luspai, K.; Kozisek, J.  Inorganic Chemistry 2011, 50, 2918-2931.

 

Electron Transfer within Nitrogenase: Evidence for a Deficit-Spending Mechanism, Danyal, K.; Dean, D. R.; Hoffman, B. M.; Seefeldt, L. C.  Biochemistry 2011, 50, 9255-9263.

 

The Structure of Formaldehyde-Inhibited Xanthine Oxidase Determined by 35 GHz 2H ENDOR Spectroscopy, Shanmugam, M.; Zhang, B.; McNaughton, R. L.; Kinney, R. A.; Hille, R.; Hoffman, B. M.  Journal of the American Chemical Society 2010, 132, 14015-14017.

 

Synthesis of Heteroatom Substituted Naphthoporphyrazine Derivatives with Near-Infrared Absorption and Emission, Trivedi, E. R.; Lee, S.; Zong, H.; Blumenfeld, C. M.; Barrett, A. G. M.; Hoffman, B. M.  Journal of Organic Chemistry 2010, 75, 1799-1802.

 

Synthesis and Characterization of New Porphyrazine-Gd(III) Conjugates as Multimodal MR Contrast Agents, Song, Y.; Zong, H.; Trivedi, E. R.; Vesper, B. J.; Waters, E.; Barrett, A. G. M.; Radosevich, J. A.; Hoffman, B. M.; Meade, T. J.  Bioconjugate Chemistry 2010, 21, 2267-2275.

 

Protonation of the Dinitrogen-Reduction Catalyst [HIPTN(3)N]Mo(III) Investigated by ENDOR Spectroscopy, Kinney, R. A.; McNaughton, R. L.; Chin, J. M.; Schrock, R. R.; Hoffman, B. M.  Inorg Chem 2010.

 

Probing the Ternary Complexes of Indoleamine and Tryptophan 2,3-Dioxygenases by Cryoreduction EPR and ENDOR Spectroscopy, Davydov, R. M.; Chauhan, N.; Thackray, S. J.; Anderson, J. L. R.; Papadopoulou, N. D.; Mowat, C. G.; Chapman, S. K.; Raven, E. L.; Hoffman, B. M.  Journal of the American Chemical Society 2010, 132, 5494-5500.

 

Probing the oxyferrous and catalytically active ferryl states of Amphitrite ornata dehaloperoxidase by cryoreduction and EPR/ENDOR spectroscopy. Detection of Compound I., Davydov, R.; Osborne, R.; Shanmugam, M.; Du, J.; Dawson, J.; Hoffman, B.  Journal of the American Chemical Society 2010, 132, 14995-15004.

 

Is Mo involved in hydride binding by the four-electron reduced (E4) intermediate of the nitrogenase MoFe protein?, Lukoyanov, D.; Yang, Z.-Y.; Dean, D. R.; Seefeldt, L. C.; Hoffman, B. M.  Journal of the American Chemical Society 2010, 132, 2526–2527.

 

Identification of a hemerythrin-like domain in a P1B-type transport ATPase, Traverso, M. E.; Subramanian, P.; Davydov, R.; Hoffman, B. M.; Stemmler, T. L.; Rosenzweig, A. C.  Biochemistry 2010, 49, 7060-8.

 

Formation of {[HIPTN3N]Mo(III)H}- by Heterolytic Cleavage of H2 as Established by EPR and ENDOR Spectroscopy, Kinney, R. A.; Hetterscheid, D. G. H.; Hanna, B. S.; Schrock, R. R.; Hoffman, B. M.  Inorganic Chemistry 2010, 49, 704-713.

 

Faster Interprotein Electron Transfer in a [Myoglobin, b5] Complex with a Redesigned Interface, Xiong, P.; Nocek, J. M.; Vura-Weis, J.; Lockard, J. V.; Wasielewski, M. R.; Hoffman, B. M.  Science 2010, 330, 1075-1078.

 

Experimental and Theoretical EPR Study of Jahn-Teller Active [HIPTN3N]MoL Complexes (L = N2, CO, NH3), McNaughton, R. L.; Roemelt, M.; Chin, J. M.; Schrock, R. R.; Neese, F.; Hoffman, B. M.  Journal of the American Chemical Society 2010, 132, 8645–8656.

 

Conformational Gating of Electron Transfer From the Nitrogenase Fe Protein to MoFe Protein, Danyal, K.; Mayweather, D.; Dean, D. R.; Seefeldt, L. C.; Hoffman, B. M.  Journal of the American Chemical Society 2010, 132, 6894–6895.

 

Chiral porphyrazine near-IR optical imaging agent exhibiting preferential tumor accumulation, Trivedi, E. R.; Harney, A. S.; Olive, M. B.; Podgorski, I.; Moin, K.; Sloane, B. F.; Barrett, A. G.; Meade, T. J.; Hoffman, B. M.  Proceedings of the National Academy of Sciences of the United States of America 2010, 107, 1284-8.

 

Chiral bis-Acetal Porphyrazines as Near-Infrared Optical Agents for Detection and Treatment of Cancer, Trivedi, E. R.; Vesper, B. J.; Weitman, H.; Ehrenberg, B.; Radosevich, J. A.; Barrett, A. G. M.; Hoffman, B. M.  Photochemistry and Photobiology 2010, 86, 410-417.

 

Photoinitiated Singlet and Triplet Electron Transfer Across a Re-Designed [Myoglobin, Cytochrome b5] Interface, Nocek, J. M.; Knutson, A. K.; Xiong, P.; Co, N. P.; Hoffman, B. M.  Journal of the American Chemical Society 2010, 132, 6165-6175.

 

Observation of Organometallic and Radical Intermediates Formed during the Reaction of Methyl-Coenzyme M Reductase with Bromoethanesulfonate, Li, X.; Telser, J.; Kunz, R. C.; Hoffman, B. M.; Gerfen, G.; Ragsdale, S. W.  Biochemistry 2010, 49, 6866–6876.

 

Probing in vivo Mn2+ Speciation and Oxidative Stress Resistance in Yeast Cells with Electron-Nuclear Double Resonance Spectroscopy, McNaughton, R. L.; Reddi, A. R.; Clement, M. H. S.; Sharma, A.; Barnese, K.; Rosenfeld, L.; Gralla, E. B.; Valentine, J. S.; Culotta, V. C.; Hoffman, B. M.  Proceedings of the National Academy of Sciences 2010, 107, 15335-15339.

 

Simulating suppression effects in Pulsed ENDOR, and the 'hole in the middle' of Mims and Davies ENDOR Spectra, Doan, P. E.; Lees, N. S.; Shanmugam, M.; Hoffman, B. M.  Applied Magnetic Resonance 2010, 37, 763-779.

 

Uncoupling Nitrogenase: Catalytic Reduction of Hydrazine to Ammonia by a MoFe Protein in the Absence of Fe Protein-ATP, Danyal, K.; Inglet, B. S.; Vincent, K. A.; Barney, B. M.; Hoffman, B. M.; Armstrong, F. A.; Dean, D. R.; Seefeldt, L. C.  Journal of the American Chemical Society 2010, 132, 13197-13199.

 

Paramagnetic Intermediates of (E)-4-Hydroxy-3-methylbut-2-enyl Diphosphate Synthase (GcpE/IspG)  under Steady-State and Pre-Steady-State Conditions, Xu, W.; Lees, N.; Adedeji, D.; Wiesner, J.; Jomaa, H.; Hoffman, B.; Duin, E.  Journal of the American Chemical Society 2010, 132, 14509-14520.