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The Hoffman Group

● Trapping an Intermediate of Dinitrogen (N2) Reduction on Nitrogenase.    Barney, B. M.; Lukoyanov, D.; Igarashi, R. Y.; Laryukhin, M.; Yang, T.-C.; Dean, D. R.; Hoffman, B. M.; Seefeldt, L. C.  Biochemistry  2009, ACS Just Accepted. 

● Synthesis and characterization of periphery-functionalized porphyrazines containing mixed pyrrolyl and pyridylmethyl-amino groups.    Goslinski, T.; Tykarska, E.; Szczolko, W.; Osmalek, T.; Smigielska, A.; Walorczyk, S.; Zong, H.; Gdaniec, M.; Hoffman, B. M.; Mielcarek, J.; Sobiak, S.  Journal of Porphyrins and Phthalocyanines  2009,  13(2),  223-234.

● Serendipitous synthesis of trimetallic porphyrazine triads.  Goslinski, T.; Zhong, C.; Fuchter, M. J.; White, A. J. P.; Barrett, A. G. M.; Hoffman, B. M.    Tetrahedron Letters  2009,  50(37),  5178-5181. 

● ENDOR Spectroscopy Shows That Guanine N1 Binds to [4Fe-4S] Cluster II of the S-Adenosylmethionine-Dependent Enzyme MoaA: Mechanistic Implications.    Lees, N. S.; Hanzelmann, P.; Hernandez, H. L.; Subramanian, S.; Schindelin, H.; Johnson, M. K.; Hoffman, B. M.  Journal of the American Chemical Society 2009,  131(26),  9184-9185. 

● Identification of Protonated Oxygenic Ligands of Ribonucleotide Reductase Intermediate X.    Shanmugam, M.; Doan, P. E.; Lees, N. S.; Stubbe, J.; Hoffman, Brian M.  Journal of the American Chemical Society 2009,  131(9),  3370-3376. 

● Mechanism of Mo-dependent nitrogenase.    Seefeldt, L. C.; Hoffman, B. M.; Dean, D. R.  Annual Review of Biochemistry  2009,  78,  701-722. 

● Electrostatic Redesign of the [Myoglobin, Cytochrome b5] Interface To Create a Well-Defined Docked Complex with Rapid Interprotein Electron Transfer.    Xiong, P.; Nocek, J. M.; Griffin, A. K. K.; Wang, J.; Hoffman, B. M.  Journal of the American Chemical Society  2009,  131(20),  6938-6939. 

● Climbing Nitrogenase: Toward a Mechanism of Enzymatic Nitrogen Fixation, Hoffman, B. M.; Dean, D. R.; Seefeldt, L. C.  Accounts of Chemical Research 2009, 42(5), 609-619.

● ENDOR Characterization of a Synthetic Diiron Hydrazido Complex as a Model for Nitrogenase Intermediates.    Lees, N. S.; McNaughton, R. L.; Vargas Gregory, W.; Holland, P. L.; Hoffman, B M. Journal of the American Chemical Society  2008,  130(2),  546-555. 

● Kinetic-Dynamic Model for Conformational Control of an Electron Transfer Photocycle: Mixed-Metal Hemoglobin Hybrids, Patel, A. D.; Nocek, J. M.; Hoffman, B. M.  Journal of Physical Chemistry B 2008, 112(37), 11827-11837.

● Characterization of the Microsomal Cytochrome P450 2B4 O₂-Activation Intermediates by Cryoreduction and EPR, Davydov, R.; Razeghifard, R.; Im, S.-C.; Waskell, L.; Hoffman, B. M.  Biochemistry 2008, 47(36), 9661-9666.

● Synthesis and Biological Analysis of Thiotetra(ethylene glycol) monomethyl Ether-Functionalized Porphyrazines: Cellular Uptake and Toxicity Studies, Lee, S.; Vesper Benjamin, J.; Zong, H.; Hammer Neal, D.; Elseth Kim, M.; Barrett Anthony, G. M.; Hoffman Brian, M.; Radosevich James, A. Metal-based drugs 2008, 2008, 391418.

● The Metal Centers of Particulate Methane Monooxygenase from Methylosinus trichosporium OB3b, Hakemian, A. S.; Kondapalli, K. C.; Telser, J.; Hoffman, B. M.; Stemmler, T. L.; Rosenzweig, A. C.  Biochemistry 2008, 47(26), 6793-6801.

● Spectroscopy, binding to liposomes and production of singlet oxygen by porphyrazines with modularly variable water solubility, Sholto, A.; Lee, S.; Hoffman, B. M.; Barrett, A. G. M.; Ehrenberg, B.  Photochemistry and Photobiology 2008, 84(3), 764-773.

● EPR and ENDOR studies of Fe(II) hemoproteins reduced and oxidized at 77 K, Davydov, R.; Hoffman, B. M.  Journal of Biological Inorganic Chemistry 2008, 13(3), 357-369.

● EPR and ENDOR Studies of cryoreduced Compounds II of peroxidases and myoglobin. Proton-coupled electron transfer and Protonation status of ferryl hemes, Davydov, R.; Osborne, R. L.; Kim, S. H.; Dawson, J. H.; Hoffman, B. M.  Biochemistry 2008, 47(18), 5147-5155.

● Porphyrazines: Designer Macrocycles by Peripheral Substituent Change, Fuchter, M. J.; Zhong, C.; Zong, H.; Hoffman, B. M.; Barrett, A. G. M.  Australian Journal of Chemistry 2008, 61, 1-21.

● Nuclear relaxation effects in Davies ENDOR variants, Morton, J. J. L.; Lees, N. S.; Hoffman, B. M.; Stoll, S.  Journal of Magnetic Resonance 2008, 191, 315-321.

● ENDOR Characterization of a Synthetic Diiron Hydrazido Complex as a Model for Nitrogenase Intermediates, Lees, N. S.; McNaughton, R. L.; Gregory, W. V.; Vela, J.; Holland, P. L.; Hoffman, B. M.  Journal of the American Chemical Society 2007, 130, 546-555.

● Multigram Synthesis of a Water-Soluble Porphyrazine and Derived seco-Porphyrazine Labeling Agents, Guinchard, X.; Fuchter, M. J.; Ruggiero, A.; Duckworth, B. J.; Barrett, A. G. M.; Hoffman, B. M.  Organic Letters 2007, 9, 5291-5294.

● Testing if  the Interstitial Atom, X, of the Nitrogenase Molybdenum-Iron Cofactor is N or C: ENDOR, ESEEM, and DFT Studies of the S = 3/2 Resting State in Multiple Environments, Lukoyanov, D.; Pelmenschikov, V.; Maeser, N.; Laryukhin, M.; Yang, T. C.; Noodleman, L.; Dean, D. R.; Case, D. A.; Seefeldt, L. C.; Hoffman, B. M.  Inorganic Chemistry 2007, 46, 11437-11449.

● Dioxygen activation at non-heme diiron centers: oxidation of a proximal residue in the |100W variant of toluene/o-xylene monooxygenase hydroxylase, Murray, L.; Naik, S.; McCormick, M.; Davydov, R.; Garcia-Serres, R.; Kim, S. H.; Hoffman, B. M.; Huynh, B. H.; Lippard, S. J.  Biochemistry 2007, 46, 14795-14809.

● Biochemical and Spectroscopic Studies of the Electronic Structure and Reactivity of a Methyl-Ni Species Formed on Methyl-Coenzyme M Reductase, Dey, M.; Telser, J.; Kunz, R. C.; Lees, N. S.; Ragsdale, S. W.; Hoffman, B. M.  Journal of the American Chemical Society 2007, 129, 11030-11032.

● The Ups and Downs of Feher-Style ENDOR, Doan, P. E.; Gurbiel, R. J.; Hoffman, B. M.  Applied Magnetic Resonance 2007, 31, 649-663.

● Characterization and Structure of a Zn2+ and [2Fe-2S]-Containing Copper Chaperone from Archaeoglobus fulgidus, Sazinsky, M. H.; LeMoine, B.; Orofino, M.; Davydov, R.; Bencze, K. Z.; Stemmler, T. L.; Hoffman, B. M.; Argüello, J. M.; Rosenzweig, A. C.  Journal of Biological Chemistry 2007, 282, 25950-25959.

● Diazene (HN=NH) Is a Substrate for Nitrogenase: Insights into the N₂ Reduction Reaction Pathway, Barney, B. M.; McClead, J.; Lukoyanov, D.; Laryukhin, M.; Yang, T. C.; Hoffman, B. M.; Dean, D. R.; Seefeldt, L. C.  Biochemistry 2007, 46, 6784-6794.

● Dynamic Docking of Cytochrome b5 With Myoglobin and α-Hemoglobin: Heme-Neutralization 'Squares' and the Binding of Electron-Transfer-Reactive Configurations, Wheeler, K. E.; Nocek, J. M.; Cull, D. A.; Yatsunyk, L. A.; Rosenzweig, A. C.; Hoffman, B. M.  Journal of the American Chemical Society 2007, 129, 3906-3917.

● Distinct Reaction Pathways Followed upon Reduction of Oxy-Heme Oxygenase and Oxy-Myoglobin as Characterized by Moessbauer Spectroscopy, Garcia-Serres, R.; Davydov, R. M.; Matsui, T.; Ikeda-Saito, M.; Hoffman, B. M.; Huynh, B. H.  Journal of the American Chemical Society 2007, 129, 1402-1412.

● EPR Study of the Low-Spin [d³; S =1/2], Jahn-Teller-Active, Dinitrogen Complex of a Molybdenum Trisamidoamine, McNaughton, R. L.; Chin, J. M.; Weare, W. W.; Schrock, R. R.; Hoffman, B. M.  Journal of the American Chemical Society 2007, 129, 3480-3481.

● Connecting nitrogenase intermediates with the kinetic scheme for N₂ reduction by a relaxation protocol and identification of the N₂ binding state, Lukoyanov, D.; Barney, B. M.; Dean, D. R.; Seefeldt, L. C.; Hoffman, B. M.  Proceedings of the National Academy of Sciences 2007, 104, 1451-1455.

● Comparing the electronic properties of the low-spin cyano-ferric [Fe(N₄)(Cys)] active sites of superoxide reductase and P450cam using ENDOR spectroscopy and DFT calculations, Yang, T.-C.; McNaughton, R. L.; Clay, M. D.; Francis E. Jenney, J.; Krishnan, R.; Donald M. Kurtz, J.; Adams, M. W. W.; Johnson, M. K.; Hoffman, B. M.  Journal of the American Chemical Society 2006, 128, 16566-16578.

● Nitrogen Fixation Special Feature: A methyldiazene (HN=N-CH₃)-derived species bound to the nitrogenase active-site FeMo cofactor: Implications for mechanism, Barney, B. M.; Lukoyanov, D.; Yang, T.-C.; Dean, D. R.; Hoffman, B. M.; Seefeldt, L. C.  PNAS %R 10.1073/pnas.0602130103 2006, 103, 17113-17118.

● NMR Spectroscopy Can Characterize Proteins Encapsulated in a Sol-Gel Matrix, Wheeler, K. E.; Nocek, J. M.; Hoffman, B. M.  Journal of the American Chemical Society 2006, 128, 14782-14783.

● Probing Surface-Porphyrazine Reduction Potentials by Molecular Design, Sun, P.; Zong, H.; Salaita, K.; Ketter, J. B.; Barrett, A. G. M.; Hoffman, B. M.; Mirkin, C. A.  Journal of Physical Chemistry B 2006, 110, 18151-18153.

● Porphyrazines as Molecular Scaffolds: Flexible Syntheses of Novel Multimetallic Complexes, Goslinski, T.; Zhong, C.; Fuchter, M. J.; Stern, C. L.; White, A. J. P.; Barrett, A. G. M.; Hoffman, B. M.  Inorganic Chemistry 2006, 45, 3686-3694.

● Demonstration by ²H ENDOR Spectroscopy that myo-Inositol Binds via an Alkoxide Bridge to the Mixed-Valent Diiron Center of myo-Inositol Oxygenase, Kim, S. H.; Xing, G.; Bollinger, J. M., Jr.; Krebs, C.; Hoffman, B. M.  Journal of the American Chemical Society 2006, 128, 10374-10375.

● Characterization of the Particulate Methane Monooxygenase Metal Centers in Multiple Redox States by X-ray Absorption Spectroscopy, Lieberman, R. L.; Kondapalli, K. C.; Shrestha, D. B.; Hakemian, A. S.; Smith, S. M.; Telser, J.; Kuzelka, J.; Gupta, R.; Borovik, A. S.; Lippard, S. J.; Hoffman, B. M.; Rosenzweig, A. C.; Stemmler, T. L.  Inorganic Chemistry 2006, 45, 8372-8381.

● How an Enzyme Tames Reactive Intermediates: Positioning of the Active-Site Components of Lysine 2,3-aminomutase During Enzymatic Turnover as Determined by ENDOR Spectroscopy, Lees, N. S.; Chen, D.; Walsby, C. J.; Behshad, E.; Frey, P. A.; Hoffman, B. M.  Journal of the American Chemical Society 2006, 128, 10145-10154.

● A Davies/Hahn Multi-Sequence for Studies of Spin Relaxation in Pulsed ENDOR, Yang, T.-C.; Hoffman, B. M.  Journal of Magnetic Resonance 2006, 181, 280-286.

● Breaking the N₂ Triple Bond: Insights into the Nitrogenase Mechanism, Seefeldt, L. C.; Dean, D. R.; Hoffman, B. M.; Dos Santos, P.; Barney, B. M.; Lee, H. I.  Dalton Transactions 2006, 2277-2284.

● Porphyrazines Peripherally Functionalized with Hybrid Ligands as Molecular Scaffolds for Bimetallic Metal-Ion Coordination, Zhong, C.; Zhao, M.; Goslinski, T.; Stern, C.; Barrett, A. G. M.; Hoffman, B. M.  Inorganic Chemistry 2006, 45, 3983-3989.

● Rapid Freeze-Quench ENDOR Study of Chloroperoxidase Compound I: The Site of the Radical, Kim, S. H.; Perera, R.; Hager, L. P.; Dawson, J. H.; Hoffman, B. M.  Journal of the American Chemical Society 2006, 128, 5598-5599.

● Developing a structure-function relationship for anionic porphyrazines exhibiting selective anti-tumor activity, Vesper, B. J.; Lee, S.; Hammer, N. D.; Elseth, K. M.; Barrett, A. G. M.; Hoffman, B. M.; Radosevich, J. A.  Journal of Photochemistry and Photobiology, B: Biology 2006, 82, 180-186.

● Ring-Opening Metathesis Polymer Sphere-Supported seco-Porphyrazines: Efficient and Recyclable Photooxygenation Catalysts, Fuchter, M. J.; Hoffman, B. M.; Barrett, A. G. M.  Journal of Organic Chemistry 2006, 71, 724-729.

● Compound I of heme oxygenase cannot hydroxylate its heme meso-carbon, Matsui, T.; Kim, S. H.; Jin, H.; Hoffman, B. M.; Ikeda-Saito, M.  Journal of the American Chemical Society 2006, 128, 1090-1091.

● Geometries and Electronic Structures of Cyanide Adducts of the Non-Heme Iron Active Site of Superoxide Reductases: Vibrational and ENDOR Studies, Clay, M. D.; Yang, T.-C.; Jenney, F. E., Jr.; Kung, I. Y.; Cosper, C. A.; Krishnan, R.; Kurtz, D. M., Jr.; Adams, M. W. W.; Hoffman, B. M.; Johnson, M. K.  Biochemistry 2006, 45, 427-438.